Development of neurodegeneration in amyotrophic lateral sclerosis: from up or down?
| Autor: | Felix Geser, Gregor K. Wenning, Johannes Haybaeck, Lisa Fellner |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Nervous system medicine.medical_specialty Neurology Disease Lower motor neuron 03 medical and health sciences 0302 clinical medicine medicine Humans Amyotrophic lateral sclerosis Biological Psychiatry Inclusion Bodies Upper motor neuron business.industry Neurodegeneration Amyotrophic Lateral Sclerosis Motor neuron medicine.disease DNA-Binding Proteins Psychiatry and Mental health 030104 developmental biology medicine.anatomical_structure Neurology (clinical) business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Journal of neural transmission (Vienna, Austria : 1996). 127(8) |
| ISSN: | 1435-1463 |
| Popis: | Amyotrophic lateral sclerosis (ALS) is a fatal neurological disease associated with neurodegeneration and intracellular pathological 43-kDa transactive response sequence DNA-binding protein (TDP-43) positive inclusions. The various clinical symptoms, such as motor disorders and cognitive impairment, reflect the degeneration of certain areas of the nervous system. Since the discovery of the significance of pathological TDP-43 for human disease including ALS, there has been an increasing number of studies reporting on the distribution and severity of neurodegeneration. These have rekindled the old debate about whether the first or second motor neuron is the primary site of degeneration in ALS. To shed light on this question, the following is a review of the relevant neuropathological studies. |
| Databáze: | OpenAIRE |
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