Neurotrophin-3 mRNA expression in rat intrafusal muscle fibres after denervation and reinnervation
| Autor: | Nieske Brouwer, J.C.V.M. Copray |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
neurotrophic factors
Nerve Crush medicine.medical_treatment proprioception Muscle Fibers Skeletal MOTONEURONS In situ hybridization Neurotrophin-3 Neurotrophin 3 Gene expression medicine Animals Nerve Growth Factors RNA Messenger Rats Wistar Muscle Spindles Denervation NEONATAL RATS biology SPINDLES General Neuroscience intrafusal fibres NERVE GROWTH-FACTOR Skeletal muscle Cell biology Nerve Regeneration Rats axotomy Nerve growth factor medicine.anatomical_structure Animals Newborn biology.protein MOTOR-NEURON SURVIVAL SKELETAL-MUSCLE Axotomy Neuroscience Reinnervation neurotrophin-3 mRNA |
| Zdroj: | Neuroscience Letters, 236(1), 41-44. ELSEVIER IRELAND LTD |
| ISSN: | 0304-3940 |
| Popis: | We have studied the regulation of the expression of neurotrophin-3 (NT-3) mRNA in neonatal and adult rat muscle spindles after denervation and after denervation followed by reinnervation. Denervation of the intrafusal fibres did not result in an upregulation of the NT-3 mRNA expression but decreased this expression below the detection limit of the in situ hybridization method. Reinnervation of intrafusal fibres restored the NT-3 mRNA expression. The results suggest that the expression of NT-3 mRNA in postnatal muscle spindles is controlled by neuronal factors. The intrafusal fibre derived NT-3 may act as an instructive, feedback messenger for innervating neurons and may play a role in stabilizing and maintaining functional neuromuscular connections. (C) 1997 Elsevier Science Ireland Ltd. |
| Databáze: | OpenAIRE |
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