Calcitonin gene-related peptide- and adrenomedullin-induced facilitation of calcium current in submandibular ganglion
| Autor: | Hideki Ichikawa, Takayuki Endoh, Masakazu Tazaki, Takashi Inoue, Maki Tsumura, Yoshiyuki Shibukawa |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Patch-Clamp Techniques Calcitonin Gene-Related Peptide Submandibular Gland Saliva secretion Calcitonin gene-related peptide Cyclase Adrenomedullin stomatognathic system Internal medicine Cricetinae medicine Animals General Dentistry Neurons Analysis of Variance Parasympathetic ganglion Mesocricetus Chemistry Calcium channel Ganglia Parasympathetic Cell Biology General Medicine Submandibular ganglion Endocrinology Otorhinolaryngology Calcitonin Calcium Channels Salivation Adenylyl Cyclases |
| Zdroj: | Archives of oral biology. 56(2):187-193 |
| Popis: | Objective The control of saliva secretion is mainly under parasympathetic control. The submandibular ganglion (SMG) is a parasympathetic ganglion which receives inputs from preganglionic cholinergic neurons, and innervates the submandibular salivary gland to control saliva secretion. The aim of this study was to investigate if adrenomedullin (ADM) and/or calcitonin gene-related peptide (CGRP) modulate voltage-dependent calcium channel (VDCCs) current ( I Ca ) in SMG. Design The profile of CGRP and ADM actions in SMG was studied using the whole-cell configuration of the patch-clamp technique. Results Both ADM and CGRP facilitated I Ca . These facilitations were attenuated by intracellular dialysis of the anti-Gα s -protein and pretreatment of SQ22536 (an adenylate cyclase inhibitor). Conclusions ADM and CGRP facilitates VDCCs mediated by Gα s -protein and adenylate cyclase in SMG. |
| Databáze: | OpenAIRE |
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