Turning the Tide: Natural Products and Natural-Product-Inspired Chemicals as Potential Counters to SARS-CoV-2 Infection
| Autor: | Liyan Yang, Zhonglei Wang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
2019-20 coronavirus outbreak Coronavirus disease 2019 (COVID-19) natural products Highly pathogenic Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses Mini Review SARS-Cov-2 Natural (archaeology) 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Medicine potential anti-SARSCoV-2 agents Pharmacology (medical) Pharmacology natural-product-inspired Natural product business.industry lcsh:RM1-950 virus diseases COVID-19 Virology Carolacton 030104 developmental biology lcsh:Therapeutics. Pharmacology chemistry 030220 oncology & carcinogenesis Homoharringtonine business |
| Zdroj: | Frontiers in Pharmacology Frontiers in Pharmacology, Vol 11 (2020) |
| ISSN: | 1663-9812 |
| Popis: | The novel and highly pathogenic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), has become a continued focus of global attention due to the serious threat it poses to public health. There are no specific drugs available to combat SARS-CoV-2 infection. Natural products (carolacton, homoharringtonine, emetine, and cepharanthine) and natural product-inspired small molecules (ivermectin, GS-5734, EIDD-2801, and ebselen) are potential anti-SARS-CoV-2 agents that have attracted significant attention due to their broad-spectrum antiviral activities. Here, we review the research on potential landmark anti-SARS-CoV-2 agents, systematically discussing the importance of natural products and natural-product-inspired small molecules in the research and development of safe and effective antiviral agents. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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