ERG Rearrangement for Predicting Subsequent Cancer Diagnosis in High-Grade Prostatic Intraepithelial Neoplasia and Lymph Node Metastasis
| Autor: | Xin Gao, Li Ling, Xian Zhong Bai, Fang Jian Zhou, Ke Ji Xie, Jian Guang Qiu, Xing Qiao Wen, Hao Zhang, Qi Peng Sun, Ming Kun Chen, Ming Yang, Chun Kui Shao, Xiang Fu Zhou, Jun Pang, Zu Lan Su, Zhong Chen, Liao Yuan Li |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Oncology Cancer Research medicine.medical_specialty genetic structures Biopsy Risk Assessment Sensitivity and Specificity Prostate cancer Transcriptional Regulator ERG Predictive Value of Tests Risk Factors Internal medicine Humans Medicine High-grade prostatic intraepithelial neoplasia Lymph node In Situ Hybridization Fluorescence Aged Neoplasm Staging Aged 80 and over Gene Rearrangement Prostatectomy Prostatic Intraepithelial Neoplasia Intraepithelial neoplasia business.industry Prostatic Neoplasms Cancer Gene rearrangement Middle Aged Prognosis medicine.disease Immunohistochemistry eye diseases medicine.anatomical_structure Lymphatic Metastasis Trans-Activators sense organs Neoplasm Grading business Erg |
| Zdroj: | Clinical Cancer Research. 18:4163-4172 |
| ISSN: | 1557-3265 1078-0432 |
| Popis: | Purpose: We aimed to analyze whether ERG rearrangement in biopsies could be used to assess subsequent cancer diagnosis in high-grade prostatic intraepithelial neoplasia (HGPIN) and the risk of lymph node metastasis in early prostate cancer. Experimental Design: Samples from 523 patients (361 with early prostate cancer and 162 with HGPIN) were collected prospectively. On the basis of the cutoff value established previously, the 162 patients with HGPIN were stratified to two groups: one with an ERG rearrangements rate ≥1.6% (n = 59) and the other with an ERG rearrangements rate Results: A total of 56 (of 59, 94.9%) HGPIN cases with an ERG rearrangements rate ≥1.6% and 5 (of 103, 4.9%) HGPIN cases with an ERG rearrangements rate Conclusions: The presence of ERG rearrangement in HGPIN lesions detected on initial biopsy warrants repeat biopsies and measuring ERG rearrangement could be used for assessing the risk of lymph node metastasis in early prostate cancer. Clin Cancer Res; 18(15); 4163–72. ©2012 AACR. |
| Databáze: | OpenAIRE |
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