Cyclooxygenase-2 polymorphisms were associated with the risk of gastric cancer: evidence from a meta-analysis based on case-control studies
| Autor: | Chang Fu Nie, Wen Feng Yan, Pei Chun Sun, Gang Wu |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Genotype Bioinformatics Gastroenterology Polymorphism Single Nucleotide White People Asian People Gene Frequency Risk Factors Stomach Neoplasms Internal medicine Odds Ratio Medicine Humans Genetic Predisposition to Disease Allele biology business.industry Case-control study General Medicine Odds ratio Confidence interval Increased risk Cyclooxygenase 2 Meta-analysis Case-Control Studies biology.protein Cyclooxygenase Cancer development business |
| Zdroj: | Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 34(6) |
| ISSN: | 1423-0380 |
| Popis: | The associations between cyclooxygenase-2 (COX-2) polymorphisms (-765GC, -1195GA, and -587GA) and risk of gastric cancer have been investigated, but the results were inconsistent. The aim of this study was to explore the associations between COX-2 polymorphisms and risk of gastric cancer using a meta-analytic method. We searched the databases of PubMed, Embase, and Wanfang (Chinese database) to identify the eligible studies. Odds ratio and 95 % confidence interval (OR and 95% CI) were used as effect size, and combined analyses were conducted using fixed- or random-effects model. Overall, ten studies for COX-2-765GC, six studies for -1195GA, and three studies for -587GA were included in this study. The results for combined analysis for COX-2-765GC indicated that C allele was significantly associated with increased risk of gastric cancer compared with G allele, especially for Asians (OR and 95 % CI: 1.58 (1.06-2.35), P(z-test) = 0.03, and P heterogeneity0.01 for CC+GC vs. GG). In addition, the A allele of COX-2-1195GA was also significantly associated with risk of gastric cancer compared with G allele (OR and 95 % CI: 1.20 (1.09-1.32), P(z-test)0.001, and P(heterogeneity) = 0.82 for A carriers vs. G carriers). In contrast, the COX-2-587GA polymorphism was not associated with risks of gastric cancer. In summary, this meta-analysis indicated that the COX-2-765GC and -1195GA polymorphisms were significantly associated with risk of gastric cancer development. |
| Databáze: | OpenAIRE |
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