Is inhibin B involved in the toxic effect of lead on male reproduction?
| Autor: | Philippe Kiss, Michel Vanhoorne, Dirk De Bacquer, Ahmed Mahmoud, Frank Comhaire |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Urology Endocrinology Diabetes and Metabolism Biology Semen analysis Body Mass Index Follicle-stimulating hormone Belgium Occupational Exposure Internal medicine medicine Humans Inhibins Spermatogenesis Sperm motility Sertoli Cells Sperm Count medicine.diagnostic_test Reproduction Middle Aged Sertoli cell Sperm Lead Poisoning Cross-Sectional Studies Fertility Endocrinology medicine.anatomical_structure Lead Reproductive Medicine Toxicity Regression Analysis Population study hormones hormone substitutes and hormone antagonists |
| Zdroj: | International Journal of Andrology. 28:150-155 |
| ISSN: | 1365-2605 0105-6263 |
| DOI: | 10.1111/j.1365-2605.2005.00524.x |
| Popis: | Summary Human studies indicate exposure to lead is associated with decreased sperm quality with modest, if any, effects on conventional reproductive endocrine profile. Inhibin B is a marker of Sertoli cell function and spermatogenesis. The present study evaluates possible effects of lead exposure on serum levels of inhibin B in a group of lead workers as compared with a non-exposed group of hospital personnel. The study population included 68 healthy Belgian workers from a lead smelter (Hoboken, Belgium) and for comparison a control group of 91 hospital personnel (University Hospital Ghent, Belgium). Semen analysis and measurement of current blood lead levels and serum levels of inhibin B, follicle stimulating hormone (FSH) and estradiol (E2). Lead workers had significantly lower sperm concentration (35 vs. 51 million/mL) and higher serum inhibin B (259 vs. 177 pg/mL) as well as lead blood levels 30.9 vs. 3.4 μg/dL) compared with the hospital personnel (all p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|