Early environmental enrichment affects neurobehavioral development and prevents brain damage in rats submitted to neonatal hypoxia-ischemia
| Autor: | Bruna Ferrary Deniz, Lenir Orlandi Pereira, Joseane Jiménez Rojas, Ramiro Diaz, Clarissa Pedrini Schuch, Iohanna Deckmann |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Physiology Neocortex Brain damage Striatum Environment Corpus callosum Corpus Callosum 03 medical and health sciences 0302 clinical medicine Atrophy Reflex medicine Animals Rats Wistar Environmental enrichment General Neuroscience Brain Organ Size medicine.disease Corpus Striatum Perinatal asphyxia 030104 developmental biology medicine.anatomical_structure Animals Newborn Anesthesia Hypoxia-Ischemia Brain Female medicine.symptom Psychology 030217 neurology & neurosurgery |
| Zdroj: | Neuroscience Letters. 617:101-107 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/j.neulet.2016.02.015 |
| Popis: | Our previous results demonstrated improved cognition in adolescent rats housed in environmental enrichment (EE) that underwent neonatal hypoxia-ischemia (HI). The aim of this study was to investigate the effects of early EE on neurobehavioral development and brain damage in rats submitted to neonatal HI. Wistar rats were submitted to the HI procedure on the 7th postnatal day (PND) and housed in an enriched environment (8th-20th PND). The maturation of physical characteristics and the neurological reflexes were evaluated and the volume of striatum, corpus callosum and neocortex was measured. Data analysis demonstrated a clear effect of EE on neurobehavioral development; also, daily performance was improved in enriched rats on righting, negative geotaxis and cliff aversion reflex. HI caused a transient motor deficit on gait latency. Brain atrophy was found in HI animals and this damage was partially prevented by the EE. In conclusion, early EE stimulated neurobehavioral development in neonate rats and also protects the neocortex and the corpus callosum from atrophy following HI. These findings reinforce the potential of EE as a strategy for rehabilitation following neonatal HI and provide scientific support to the use of this therapeutic strategy in the treatment of neonatal brain injuries in humans. |
| Databáze: | OpenAIRE |
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