Neuromuscular changes with alloxan hyperglycemia: Electrophysiological, biochemical, and histological study in rats
| Autor: | Christian Coërs, Alfred Joffroy, Guy Graff, Jeanne Hildebrand |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1968 |
| Předmět: |
Muscle tissue
Pathology medicine.medical_specialty Diabetic neuropathy Neuromuscular Junction Neural Conduction Action Potentials Synaptic Transmission Nerve conduction velocity Diabetes Mellitus Experimental chemistry.chemical_compound Neuromuscular Junction -- pathology -- physiopathology Arts and Humanities (miscellaneous) Alloxan Diabetes mellitus Neurologie Ranvier's Nodes Medicine Animals Muscle Spindles Evoked Potentials Subclinical infection Phosphorus -- metabolism business.industry Muscle Spindles -- pathology -- physiopathology Phosphorus Anatomy Collateral sprouting Sciatic Nerve -- metabolism -- pathology -- physiopathology medicine.disease Sciatic Nerve Rats Electrophysiology Muscular Atrophy medicine.anatomical_structure chemistry Nerve Degeneration Neurology (clinical) Schwann Cells business Demyelinating Diseases |
| Zdroj: | Archives of neurology, 18 |
| Popis: | CHANGES in peripheral nerves occurring in diabetes have been extensively studied during the past few years by refined electrophysiological and histological methods. The most common functional change is a slowing in nerve conduction velocity 1 which may be present without clinical signs of motor or even sensory involvement, and therefore has proved to be the expression of a latent neuropathy. 2 It was later recognized that the reduction of conduction velocity was related to a segmental demyelination of the nerve fibers, and that the diabetic neuropathy was a prominently demyelinating condition, although axonal degeneration could occur as well. 3 The histological study of intramuscular innervation and muscle tissue in diabetic patients disclosed a high incidence of subclinical changes and made it possible to describe the various steps of neuromuscular aggression. 4,5 An early reduction or an abnormal extension of the motor end plates are followed by collateral sprouting of |
| Databáze: | OpenAIRE |
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