Combination of Dose Escalation with Technological Advances (Intensity-Modulated and Image-Guided Radiotherapy) Is Not Associated with Increased Morbidity for Patients with Prostate Cancer
| Autor: | Michael J. Eble, Jens Klotz, Richard Holy, Michael Pinkawa, Barbara Krenkel, Victoria Djukic, Marc D. Piroth |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Urinary system Prostate cancer Imaging Three-Dimensional Erectile Dysfunction Quality of life medicine Humans Radiology Nuclear Medicine and imaging Prospective Studies Radiation Injuries Aged Neoplasm Staging Image-guided radiation therapy Aged 80 and over business.industry Radiotherapy Planning Computer-Assisted Rectum Prostatic Neoplasms Radiotherapy Dosage Middle Aged medicine.disease Surgery Radiation therapy Oncology Quality of Life Defecation Prostate neoplasm Radiotherapy Intensity-Modulated Radiology Radiotherapy Conformal Sexual function business Algorithms Follow-Up Studies |
| Zdroj: | Strahlentherapie und Onkologie. 187:479-484 |
| ISSN: | 1439-099X 0179-7158 |
| DOI: | 10.1007/s00066-011-2249-z |
| Popis: | The aim was to evaluate treatment-related morbidity after intensity-modulated (IMRT) and image-guided (IGRT) radiotherapy with a total dose of 76 Gy in comparison to conventional conformal radiotherapy (3DCRT) up to 70.2–72 Gy for patients with prostate cancer. All patients were prospectively surveyed prior to, on the last day, as well as after a median time of 2 and 16 months after RT using a validated questionnaire (Expanded Prostate Cancer Index Composite). Criteria for the 78 matched pairs after IMRT vs. 3DCRT were patient age, use of antiandrogens, treatment volume (± whole pelvis), prognostic risk group, and urinary/bowel/sexual quality of life (QoL) before treatment. QoL changes after dose-escalated IMRT were found to be similar to QoL changes after 3DCRT in all domains. Only sexual function scores more than 1 year after RT decreased slightly more after 3DCRT in comparison to IMRT (mean 9 vs. 6 points; p = 0.04), with erections firm enough for intercourse in 14% vs. 30% (p = 0.03). Painful bowel movements were reported more frequently after 3DCRT vs. IMRT 2 months after treatment (≥ once a day in 10% vs. 1%; p = 0.03), but a tendency for higher rectal bleeding rates was found after IMRT vs. 3DCRT more than 1 year after RT (≥ rarely in 20% vs. 9%; p = 0.06). Combination of dose escalation with technological advances (IMRT and IGRT) is not associated with increased morbidity for patients with prostate cancer. |
| Databáze: | OpenAIRE |
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