Oral treatment of chickens with Lactobacillus reuteri LM1 reduces Brachyspira pilosicoli-induced pathology
| Autor: | Alejandro Núñez, Luke J. Mappley, Monika A. Tchórzewska, Roberto M. La Ragione, Peter M. Bramley, Martin J. Woodward |
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| Rok vydání: | 2013 |
| Předmět: |
Limosilactobacillus reuteri
Microbiology (medical) Brachyspira Pathology medicine.medical_specialty medicine.drug_class Antibiotics Brachyspira pilosicoli Biology Microbiology Antibiotic resistance Lactobacillus medicine Animals media_common.cataloged_instance Colonization European union Poultry Diseases media_common Probiotics General Medicine biology.organism_classification Lactobacillus reuteri Gram-Negative Bacterial Infections Chickens |
| Zdroj: | Journal of Medical Microbiology. 62:287-296 |
| ISSN: | 1473-5644 0022-2615 |
| DOI: | 10.1099/jmm.0.051862-0 |
| Popis: | Avian intestinal spirochaetosis (AIS) results from the colonization of the caeca and colon of poultry by pathogenic Brachyspira, notably Brachyspira pilosicoli. Following the ban on the use of antibiotic growth promoters in the European Union in 2006, the number of cases of AIS has increased, which, alongside emerging antimicrobial resistance in Brachyspira, has driven renewed interest in alternative intervention strategies. Lactobacillus-based probiotics have been shown to protect against infection with common enteric pathogens in livestock. Our previous studies have shown that Lactobacillus reuteri LM1 antagonizes aspects of the pathobiology of Brachyspira in vitro. Here, we showed that L. reuteri LM1 mitigates the clinical symptoms of AIS in chickens experimentally challenged with B. pilosicoli. Two groups of 15 commercial laying hens were challenged experimentally by oral gavage with B. pilosicoli B2904 at 18 weeks of age; one group received unsupplemented drinking water and the other received L. reuteri LM1 in drinking water from 1 week prior to challenge with Brachyspira and thereafter for the duration of the study. This treatment regime was protective. Specifically, B. pilosicoli was detected by culture in fewer birds, bird weights were higher, faecal moisture contents were significantly lower (P |
| Databáze: | OpenAIRE |
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