Evaluation of neurobehavioral and neuroinflammatory end-points in the post-exposure period in rats sub-acutely exposed to manganese

Autor:	Dinamene, Santos, Santos, Dinamene, M Camila, Batoréu, Batoreu M, Camila, I, Tavares de Almeida, L, Davis Randall, M Luísa, Mateus, Mateus M, Luisa, Vanda, Andrade, Andrade, Vanda, Ruben, Ramos, Ramos, Ruben, Edite, Torres, Torres, Edite, Michael, Aschner, Aschner, Michael, A P, Marreilha dos Santos, A P, Marreilha Dos Santos
Rok vydání:	2013
Předmět:	Male medicine.medical_specialty Endpoint Determination medicine.medical_treatment Neurological disorder Urine Motor Activity Toxicology Article Chlorides Internal medicine Glial Fibrillary Acidic Protein medicine Manganism Animals Rats Wistar Saline Neuroinflammation Cerebral Cortex Inflammation Manganese Glial fibrillary acidic protein biology Behavior Animal Dose-Response Relationship Drug Chemistry Manganese Poisoning Spectrophotometry Atomic Brain medicine.disease Immunohistochemistry Rats medicine.anatomical_structure Endocrinology Manganese Compounds Cerebral cortex Immunology biology.protein Tumor necrosis factor alpha
Zdroj:	Toxicology. 314(1)
ISSN:	1879-3185
Popis:	Manganese (Mn) can cause manganism, a neurological disorder similar to Parkinson' Disease (PD). The neurobehavioral and neuroinflammatory end-points in the Mn post exposure period have not been studied yet. Rats were injected on alternate days with 8 doses of MnCl2 (25mg/kg) or saline, then euthanized 1, 10, 30 or 70 days following the last dose. Whole-blood (WB) (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61912acd7bc9b798f04926bf665518e9 https://pubmed.ncbi.nlm.nih.gov/24060432 Zobrazit plný text záznamu Full Text from ScienceDirect