Vascular Health and Genetic Risk Affect Mild Cognitive Impairment Status and 4-Year Stability: Evidence From the Victoria Longitudinal Study
| Autor: | Jack H. Jhamandas, Roger A. Dixon, David Westaway, David Vergote, Correne A. DeCarlo, Stuart W. S. MacDonald |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Oncology
Gerontology Apolipoprotein E Male medicine.medical_specialty Longitudinal study Aging Social Psychology Victoria Apolipoprotein E4 Disease Logistic regression Affect (psychology) Catechol O-Methyltransferase behavioral disciplines and activities 050105 experimental psychology Original Research Report 03 medical and health sciences 0302 clinical medicine Heart Rate Internal medicine mental disorders medicine Humans 0501 psychology and cognitive sciences Lung volumes Cognitive Dysfunction Longitudinal Studies Cognitive decline Aged Aged 80 and over 05 social sciences Total Lung Capacity 3. Good health Clinical Psychology Cross-Sectional Studies Cardiovascular Diseases Female Geriatrics and Gerontology Psychology human activities 030217 neurology & neurosurgery Biomarkers rs4680 |
| Popis: | Objectives Mild cognitive impairment (MCI) is a high-risk condition for progression to Alzheimer's disease (AD). Vascular health is a key mechanism underlying age-related cognitive decline and neurodegeneration. AD-related genetic risk factors may be associated with preclinical cognitive status changes. We examine independent and cross-domain interactive effects of vascular and genetic markers for predicting MCI status and stability. Method We used cross-sectional and 2-wave longitudinal data from the Victoria Longitudinal Study, including indicators of vascular health (e.g., reported vascular diseases, measured lung capacity and pulse rate) and genetic risk factors-that is, apolipoprotein E (APOE; rs429358 and rs7412; the presence vs absence of e4) and catechol-O-methyltransferase (COMT; rs4680; met/met vs val/val). We examined associations with objectively classified (a) cognitive status at baseline (not impaired congnitive (NIC) controls vs MCI) and (b) stability or transition of cognitive status across a 4-year interval (stable NIC-NIC vs chronic MCI-MCI or transitional NIC-MCI). Results Using logistic regression, indicators of vascular health, both independently and interactively with APOE e4, were associated with risk of MCI at baseline and/or associated with MCI conversion or MCI stability over the retest interval. Discussion Several vascular health markers of aging predict MCI risk. Interactively, APOE e4 may intensify the vascular health risk for MCI. |
| Databáze: | OpenAIRE |
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