Association between colchicine resistance and vitamin D in familial Mediterranean fever

Autor:	Elif Kilic Kan, Ozlem Turkeli Sezer, Guyem Kolbasi Ozgen, Gultekin Ozan Kucuk, Turkan Mete, Hacer Pinar Ozturk Kurt, Coskun Kaya, Ismail Ozer, Gulhan Duman
Přispěvatelé:	Ondokuz Mayıs Üniversitesi
Rok vydání:	2015
Předmět:	Adult Male medicine.medical_specialty Nephrology clinic Familial Mediterranean fever vitamin D Critical Care and Intensive Care Medicine Gastroenterology chemistry.chemical_compound familial Mediterranean fever Internal medicine Vitamin D and neurology medicine Effective treatment Colchicine Humans resistance to colchicines Vitamin D Decreased vitamin D business.industry General Medicine Pyrin medicine.disease Familial Mediterranean Fever Cytoskeletal Proteins Treatment Outcome chemistry Nephrology Case-Control Studies Immunology Mutation COLCHICINE RESISTANCE Female business Colchicines
Zdroj:	Renal failure. 37(7)
ISSN:	1525-6049
Popis:	SEZER, OZLEM/0000-0001-5727-7965 WOS: 000361339400009 PubMed: 26067744 Although colchicines are the only effective treatment of familial Mediterranean fever (FMF), resistance to colchicines (CR) which is observed in up to 30% of the patients is still a problem. Clinically, resistance to colchicine is defined as three or more attacks within the last 6 months period while using >= 2 mg/day colchicine. Previous studies have shown decreased vitamin D levels in FMF patients compared with healthy controls. The aim of this study is to evaluate whether vitamin D levels differ between CR and non-CR FMF patients. This study included 64 FMF patients who were being followed in Nephrology Clinic of Samsun Research and Education Hospital for at least 1 year. FMF was diagnosed according to the criteria defined by Livneh et al. Serum 25-hydroxy vitamin D (25-OHD) concentration (ng/mL) was detected in all FMF patients who were not in an acute attack period. From 64 patients 29 were accepted as CR. Mean 25-OHD level was 9.39 +/- 1.00 ng/mL in CR patients and 18.48 +/- 1.09 ng/mL in colchicine responsive patients (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61906fd05ffaa94b3c69c7162d072e20 https://pubmed.ncbi.nlm.nih.gov/26707648 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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