Mutation detection in the promoter region of survivin gene on N-methyl-N-nitrosourea induced colon tumor model in experiment
Autor: | Handan Tuncel, Mehmet Ali Korpinar, Budak M, Tunaya Kalkan |
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Rok vydání: | 2014 |
Předmět: |
Economics and Econometrics
Survivin Cellular differentiation Biology law.invention law Materials Chemistry Media Technology medicine Animals Rats Wistar Promoter Regions Genetic Gene Polymerase chain reaction Cancer Methylnitrosourea Forestry Promoter Single-strand conformation polymorphism medicine.disease Molecular biology Disease Models Animal Apoptosis Colonic Neoplasms Mutation Carcinogens Microtubule-Associated Proteins |
Zdroj: | Bratislava Medical Journal. 115:554-556 |
ISSN: | 1336-0345 |
Popis: | Survivin (also known as BIRC5) is one of the first reported inhibitors of apoptosis proteins (IAPs), which is an important family of proteins that regulate apoptosis. It is developmentally regulated and expressed during cell differentiation in humans, mice and rat. Survivin is expressed in a series of human cancers and it has been widely accepted that survivin is strongly related to the onset and development of cancer. In the present study, we tried to determine differences in the promoter region of survivin gene in colon tissue samples from N-methyl-N-nitrosourea (MNU) induced rat colon tumor model and control group. Polymerase chain reaction (PCR) - single strand conformation polymorphism (SSCP) analysis was used for this aim. No significant differences were found in the promoter region of survivin gene between the normal and tumor tissues (Tab. 2, Fig. 1, Ref. 16). |
Databáze: | OpenAIRE |
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