pH-sensitive and biocompatible quercetin-loaded GO–PEA–HA carrier improved antitumour efficiency and specificity
| Autor: | Qi Zhang, Xing Huang, Yaxiong Yi, Tong Zhang, Bing Wang, Yiqiong Pu |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Biomedical Engineering Oxide Mice Nude Pharmaceutical Science Medicine (miscellaneous) Antineoplastic Agents 02 engineering and technology 010402 general chemistry 01 natural sciences law.invention Rats Sprague-Dawley Mice chemistry.chemical_compound law Animals Humans Hyaluronic Acid Mice Inbred BALB C Chemistry Graphene Biomaterial Neoplasms Experimental General Medicine Hydrogen-Ion Concentration 021001 nanoscience & nanotechnology Biocompatible material Xenograft Model Antitumor Assays Combinatorial chemistry Anticancer drug Rats 0104 chemical sciences Delayed-Action Preparations Female Graphite Quercetin 0210 nano-technology Drug carrier Biotechnology |
| Zdroj: | Artificial Cells, Nanomedicine, and Biotechnology. 46:28-37 |
| ISSN: | 2169-141X 2169-1401 |
| Popis: | A novel drug carrier was designed based on a new biomaterial, that is, graphene oxide (GO), to improve the efficiency and specificity of anticancer drug. In this study, GO was successively modified with polyetheramine (PEA) and hyaluronic acid (HA). The carrier was utilized to load an antitumor component, that is, quercetin (Que), which was derived from traditional Chinese medicine, namely the pagoda tree flower bud. This drug delivery system (DDS) exhibited pH sensibility under subacid condition and good biocompatibility even when GO concentration reached 350 μg/mL. Moreover, the antitumor efficacy was doubly improved and more long-acting compared with Que alone. Results show that the GO-based material has potential clinical applications for antitumor drug delivery. |
| Databáze: | OpenAIRE |
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