Resveratrol-loaded folic acid-grafted dextran stearate submicron particles exhibits enhanced antitumor efficacy in non-small cell lung cancers
| Autor: | Zhi-dong Wang, Ai-wen Wang, Zhao-pei Li, Jing Liu, Qing-sheng Zhao, Ling-ling Hu |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Lung Neoplasms
Materials science Antineoplastic Agents Apoptosis Bioengineering 02 engineering and technology Resveratrol Pharmacology Micelle Biomaterials 03 medical and health sciences chemistry.chemical_compound Folic Acid 0302 clinical medicine Stearate Carcinoma Non-Small-Cell Lung Stilbenes Humans Cytotoxic T cell Particle Size bcl-2-Associated X Protein A549 cell Caspase 3 Dextrans respiratory system 021001 nanoscience & nanotechnology Mitochondria Drug Liberation Dextran chemistry Biochemistry A549 Cells Mechanics of Materials 030220 oncology & carcinogenesis Cancer cell Tumor Suppressor Protein p53 0210 nano-technology |
| Zdroj: | Materials Science and Engineering: C. 72:185-191 |
| ISSN: | 0928-4931 |
| DOI: | 10.1016/j.msec.2016.10.077 |
| Popis: | In this study, we have aimed to prepare folic acid-conjugated dextran stearate (DF) polymeric micelles to target resveratrol in lung cancers. The polymeric micelle was nanosized and exhibited a controlled drug release pattern. The resveratrol (RSV)-loaded dextran stearate (RSV-DF) micelles exhibited an enhanced cellular uptake in A549 cells due to the folic acid-based receptor interactions. We have demonstrated that RSV-DF polymeric micelles retain the cytotoxic and metabolic effects of RSV on A549 cancer cells with potencies similar to that of the free compound. Furthermore, RSV-DF showed an enhanced cellular apoptosis of cancer cells compared to that of free RSV. We have found that apoptosis induced by RSV-DF was associated with the higher expression of p53, caspase-3, and BAX than the free RSV. The higher level of BAX and caspase-3 further indicates the involvement of mitochondria-dependent apoptosis in the anticancer efficacy of formulations. Based on these results, it can be concluded that natural compound like RSV could be an interesting prospect to treat lung cancers and the fact that folic acid-conjugated dextran stearate could be a potential carrier to deliver the drug in the cancer cells. |
| Databáze: | OpenAIRE |
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