Responses of rat adrenal glomerulosa and inner zone cells to synthetic ACTH analogs and proopiomelanocortin-derived peptides
| Autor: | A.M. Capponi, Michel B. Vallotton, L.H. Jornot |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
endocrine system
medicine.medical_specialty Pro-Opiomelanocortin medicine.drug_class Adrenocorticotropic hormone Peptide hormone Biochemistry chemistry.chemical_compound Endocrinology Proopiomelanocortin Adrenocorticotropic Hormone Corticosterone Internal medicine Adrenal Glands medicine Animals Aldosterone chemistry.chemical_classification biology Rats Inbred Strains Peptide Fragments Amino acid Rats medicine.anatomical_structure chemistry Zona glomerulosa Mineralocorticoid biology.protein Female hormones hormone substitutes and hormone antagonists |
| Zdroj: | Journal of steroid biochemistry. 22(2) |
| ISSN: | 0022-4731 |
| Popis: | A comparison of the responsiveness of isolated rat adrenal decapsular and glomerulosa cells to corticotrophin 1–39 (ACTH 1–39), synthetic ACTH analogs (characterized by a shorter amino acid chain length, the substitution of certain amino acids in the natural sequence by other amino add residues, the replacement of the C-terminal carboxyl group by an amide), and proopiomelanocortin-derived peptides was performed by measuring corticosterone and aldosterone production, respectively. The potencies of the synthetic ACTH analogs correlated closely with the length of the peptides, similarly in both zones. No activity was observed with the proopiomelanocortin-derived peptides in either zone, with the exception of β-LPH and α-MSH. |
| Databáze: | OpenAIRE |
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