Serum Hepatocyte Growth Factor in Patients with Peripheral Arterial Occlusive Disease
| Autor: | Yuji Matsumoto, Yuji Yoshitomi, Morio Kuramochi, Shunichi Kojima, Michiko Yano, Toshihiko Sugi, Takuya Umemoto, Kiyokage Kubo |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Angiogenesis Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry Arterial Occlusive Diseases Biochemistry Gastroenterology Endocrinology Reference Values Risk Factors Internal medicine Angioplasty Blood plasma medicine Humans Aged Aged 80 and over Peripheral Vascular Diseases Kidney Hepatocyte Growth Factor Vascular disease business.industry Smoking Biochemistry (medical) Angiography Middle Aged medicine.disease Pathophysiology medicine.anatomical_structure Female Hepatocyte growth factor Wound healing business Vascular Surgical Procedures Angioplasty Balloon medicine.drug |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 84:2425-2428 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem.84.7.5826 |
| Popis: | Hepatocyte growth factor (HGF) is a multifunctional protein implicated in tissue regeneration, wound healing, and angiogenesis. We measured serum HGF concentrations in 37 patients with peripheral arterial occlusive disease (PAOD). Among them, 36 patients underwent arteriography. Serum HGF concentrations were also measured in 40 control subjects who remained free of vascular, liver, kidney, or lung disease. Patients with PAOD showed elevated serum HGF concentrations compared with control subjects (0.40+/-0.02 vs. 0.19+/-0.01 ng/mL; P0.001). Serum HGF concentrations were significantly higher in smokers compared with nonsmokers (0.45+/-0.03 vs. 0.35+/-0.02 ng/mL; P = 0.003). The serum HGF concentrations in patients with collaterals tended to be higher than those in patients without collaterals (0.43+/-0.03 vs. 0.35+/-0.02 ng/mL; P = 0.06). Moreover, in patients who underwent bypass surgery or angioplasty, serum HGF concentrations decreased from 0.41+/-0.03 to 0.21+/-0.04 ng/mL after treatment (P0.001). Serum HGF may be an useful marker for the diagnosis of PAOD. HGF may play an important role in angiogenesis and collateral vessel growth in PAOD. |
| Databáze: | OpenAIRE |
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