GPR120 agonists enhance the fatty orosensation when added to fat-containing system, but do not evoke it by themselves in humans
| Autor: | Iwasaki Naoya, Kazuhiro Sakamoto, Seiji Kitajima, Motonaka Kuroda, Yutaka Maruyama |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
CD36 Antigens
Linoleic acid CD36 Experimental and Cognitive Psychology Receptors G-Protein-Coupled 03 medical and health sciences Behavioral Neuroscience chemistry.chemical_compound 0302 clinical medicine medicine Humans 0501 psychology and cognitive sciences 050102 behavioral science & comparative psychology Food science Mineral oil chemistry.chemical_classification Mouth biology 05 social sciences GPR120 Fatty acid Taste Perception Oleic acid Vegetable oil chemistry Taste Emulsion biology.protein 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Physiologybehavior. 234 |
| ISSN: | 1873-507X |
| Popis: | Dietary fat, an important macronutrient, has been considered to be perceived by texture and olfaction. Recently, fatty acid transporter, CD36, and fatty acid receptor, GPR120 are considered to be involved in human gustatory fatty acids perception in humans. However, limited information is currently available to show that agonists of CD36 and GPR120 evoke fatty oral sensations regarding to dietary fat in humans. Therefore, the role of GPR120 agonists in dietary fat perception in humans was investigated herein. An emulsion prepared from vegetable oil had a stronger fatty orosensation, an orosensation similar to an oily mouth-coating sensed 5 – 10 s after tasting, than that prepared from mineral oil; however, the physical properties of both emulsions, such as viscosity, particle distribution, interfacial tension, contact angle, frictional load, and ζ-electric potential were similar. The potent GPR120 agonist, TUG-891 enhanced the fatty orosensation when added to the emulsion prepared from vegetable oil, but not to that from mineral oil. All GPR120 agonists tested enhanced the fatty orosensation when added to a low-fat food system whereas they did not evoke any fatty sensation in aqueous solution at the concentrations tested in food system, and sensory activity positively correlated with GPR120 activity. These results suggest that GPR120 agonists enhance the fatty orosensation in humans when added to vegetable oil or a low-fat food system, but do not evoke it by themselves. |
| Databáze: | OpenAIRE |
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