Altered Global Mrna Expressions Of Pain And Aggression Related Genes In The Blood Of Children With Autism Spectrum Disorders
| Autor: | Didem Behice Öztop, Mustafa Caglar Sahin, Mehmet Canpolat, Elif Funda Sener, Keziban Korkmaz Bayramov, Yusuf Ozkul, Mert Kahraman Marasli, Serpil Taheri, Gokmen Zararsiz, Ecmel Mehmetbeyoglu, Halit Canatan |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Candidate gene Neurology Autism Spectrum Disorder Bioinformatics 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Gene expression medicine Humans Neurochemistry RNA Messenger Gene Cyclic GMP-Dependent Protein Kinase Type I business.industry Aggression NAV1.7 Voltage-Gated Sodium Channel Receptors Dopamine D4 Pain Perception General Medicine medicine.disease 030104 developmental biology Autism spectrum disorder Child Preschool Receptor Serotonin 5-HT1A Receptors Opioid Autism Female medicine.symptom business 030217 neurology & neurosurgery Biomarkers |
| Popis: | Autism spectrum disorder (ASD) is characterized by repetitive stereotypic behaviors, restricted interests, social withdrawal, and communication deficits. Aggression and insensitivity to pain are largely unexplained in these cases. We analyzed nine mRNA expressions of the candidate genes related to aggression and insensitivity to pain in the peripheral blood of patients with ASD. Whole blood samples were obtained from 40 autistic patients (33 boys, 7 girls) and 50 age- and sex-matched controls (37 boys and 13 girls) to isolate RNA. Gene expression was assessed by quantitative Real-Time PCR (qRT-PCR) in the Erciyes University Genome and Stem Cell Center (GENKOK). All of the gene expressions except CRHR1 and SLC6A4 were found to be statistically different between the ASD patients and controls. Gene expression also differed according to gender. Alterations in the mRNA expression patterns of the HTR1E, OPRL1, OPRM1, TACR1, PRKG1, SCN9A and DRD4 genes provide further evidence for a relevant effect of the respective candidate genes on the pathophysiology of ASD. Future studies may determine the sensitivity of these candidate markers in larger samples including further neuropsychiatric diagnosis. |
| Databáze: | OpenAIRE |
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