Evaluation of Antibiotic Efficacy Using Electron Microscopy: Morphological Effects of Guanylureido Cephalosporin, BL-P1654, and Carbenicillin on Escherichia coli
| Autor: | R. A. Schlegel, L. K. Simmons, David A. Preston, D. K. Herron, L. F. Ellis |
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| Rok vydání: | 1976 |
| Předmět: |
Lysis
Morphology (linguistics) medicine.drug_class Cephalosporin Antibiotics Biology medicine.disease_cause Microbiology law.invention Leucine law Physiological Effects and Microbial Susceptibility polycyclic compounds Escherichia coli medicine Pharmacology (medical) Pharmacology Carbenicillin Cephalosporins Culture Media Infectious Diseases Microscopy Electron Scanning bacteria Swelling medicine.symptom Electron microscope medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 9:343-346 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.9.2.343 |
| Popis: | Early response of Escherichia coli to minimal inhibitory concentrations of 112883, BL-P1654, and carbenicillin was determined by [ 14 C]leucine uptake and scanning electron microscopy morphology studies. [ 14 C]leucine uptake was inhibited later by carbenicillin than by BL-P1654 or 112883. Cellular swelling at 30 min, septal region swelling, and lysis were the progressive morphological changes with BL-P1654 and 112883. Carbenicillin-treated cells showed septal region swelling, beaded chains, and lysis. |
| Databáze: | OpenAIRE |
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