Fucoidan But Not 2′-Fucosyllactose Inhibits Human Norovirus Replication in Zebrafish Larvae

Autor: Mohamad Eshaghi Gorji, Zhiyuan Gong, Dan Li, Malcolm Turk Hsern Tan, Yan Li
Rok vydání: 2021
Předmět:
Zdroj: Viruses, Vol 13, Iss 461, p 461 (2021)
Viruses
Volume 13
Issue 3
ISSN: 1999-4915
Popis: Human noroviruses (hNoVs) cause heavy disease burden worldwide and there is no clinically approved vaccination or antiviral hitherto. In this study, with the use of a zebrafish larva in vivo platform, we investigated the anti-hNoV potentials of fucoidan (from brown algae Fucus vesiculosus) and 2′-Fucosyllactose (2′-FL). As a result, although both fucoidan and 2′-FL were able to block hNoV GII.4 virus-like particle (VLPs) from binding to type A saliva as expected, only fucoidan, but not 2′-FL, was able to inhibit the replication of hNoV GII.P16-GII.4 in zebrafish larvae, indicating the possible needs of higher molecular weights for fucosylated carbohydrates to exert anti-hNoV effect.
Databáze: OpenAIRE
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