Fucoidan But Not 2′-Fucosyllactose Inhibits Human Norovirus Replication in Zebrafish Larvae
Autor: | Mohamad Eshaghi Gorji, Zhiyuan Gong, Dan Li, Malcolm Turk Hsern Tan, Yan Li |
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Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
Saliva viruses 030106 microbiology lcsh:QR1-502 Virus Attachment norovirus Fucus vesiculosus Biology Virus Replication medicine.disease_cause Antiviral Agents Article lcsh:Microbiology Microbiology 03 medical and health sciences chemistry.chemical_compound fluids and secretions 2'-Fucosyllactose fucoidan Polysaccharides In vivo Virology medicine Animals Humans Zebrafish Molecular mass Fucoidan virus diseases biology.organism_classification antiviral Brown algae 030104 developmental biology Infectious Diseases chemistry Larva Norovirus Trisaccharides 2′-fucosyllactose |
Zdroj: | Viruses, Vol 13, Iss 461, p 461 (2021) Viruses Volume 13 Issue 3 |
ISSN: | 1999-4915 |
Popis: | Human noroviruses (hNoVs) cause heavy disease burden worldwide and there is no clinically approved vaccination or antiviral hitherto. In this study, with the use of a zebrafish larva in vivo platform, we investigated the anti-hNoV potentials of fucoidan (from brown algae Fucus vesiculosus) and 2′-Fucosyllactose (2′-FL). As a result, although both fucoidan and 2′-FL were able to block hNoV GII.4 virus-like particle (VLPs) from binding to type A saliva as expected, only fucoidan, but not 2′-FL, was able to inhibit the replication of hNoV GII.P16-GII.4 in zebrafish larvae, indicating the possible needs of higher molecular weights for fucosylated carbohydrates to exert anti-hNoV effect. |
Databáze: | OpenAIRE |
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