Emerging rules for effective antimicrobial coatings

Autor:	Keith M. McLean, Richard A. Strugnell, Helmut Thissen, Mario Salwiczek, Yue Qu, Trevor Lithgow, James Gardiner
Rok vydání:	2014
Předmět:	Cross Infection Infection Control Bacteria biology Surface Properties medicine.drug_class Antimicrobial peptides Antibiotics Fungi Biofilm Bioengineering biology.organism_classification Antimicrobial Microbiology Anti-Infective Agents Equipment and Supplies medicine Biotechnology
Zdroj:	Trends in Biotechnology. 32:82-90
ISSN:	0167-7799
DOI:	10.1016/j.tibtech.2013.09.008
Popis:	In order to colonize abiotic surfaces, bacteria and fungi undergo a profound change in their biology to form biofilms: communities of microbes embedded into a matrix of secreted macromolecules. Despite strict hygiene standards, biofilm-related infections associated with implantable devices remain a common complication in the clinic. Here, the application of highly dosed antibiotics is problematic in that the biofilm (i) provides a protective environment for microbes to evade antibiotics and/or (ii) can provide selective pressure for the evolution of antibiotic-resistant microbes. However, recent research suggests that effective prevention of biofilm formation may be achieved by multifunctional surface coatings that provide both non-adhesive and antimicrobial properties imparted by antimicrobial peptides. Such coatings are the subject of this review.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6181f84a6f14557f0a37b7ef531b9053 https://doi.org/10.1016/j.tibtech.2013.09.008 Zobrazit plný text záznamu Full Text from ScienceDirect