Repeatability and reproducibility of human brain morphometry using three‐dimensional magnetic resonance fingerprinting
Autor: | Matteo Cencini, Akifumi Hagiwara, Shohei Fujita, Shigeki Aoki, Koji Kamagata, Naoyuki Takei, Guido Buonincontri, Issei Fukunaga, Masaaki Hori, Rolf F. Schulte, Wataru Uchida, Osamu Abe |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Adult
Male Relaxometry Materials science Intraclass correlation Coefficient of variation relaxometry 050105 experimental psychology 03 medical and health sciences Young Adult 0302 clinical medicine Technical Report Imaging Three-Dimensional Neuroimaging medicine Brain segmentation Humans 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging repeatability reproducibility Aged Reproducibility Radiological and Ultrasound Technology medicine.diagnostic_test 05 social sciences Brain Reproducibility of Results Magnetic resonance imaging Repeatability Organ Size Middle Aged Brain Cortical Thickness Magnetic Resonance Imaging Neurology human brain imaging Female Neurology (clinical) magnetic resonance fingerprinting Anatomy 030217 neurology & neurosurgery morphometry Biomedical engineering |
Zdroj: | Human Brain Mapping |
ISSN: | 1097-0193 1065-9471 |
Popis: | Three‐dimensional (3D) Magnetic resonance fingerprinting (MRF) permits whole‐brain volumetric quantification of T1 and T2 relaxation values, potentially replacing conventional T1‐weighted structural imaging for common brain imaging analysis. The aim of this study was to evaluate the repeatability and reproducibility of 3D MRF in evaluating brain cortical thickness and subcortical volumetric analysis in healthy volunteers using conventional 3D T1‐weighted images as a reference standard. Scan‐rescan tests of both 3D MRF and conventional 3D fast spoiled gradient recalled echo (FSPGR) were performed. For each sequence, the regional cortical thickness and volume of the subcortical structures were measured using standard automatic brain segmentation software. Repeatability and reproducibility were assessed using the within‐subject coefficient of variation (wCV), intraclass correlation coefficient (ICC), and mean percent difference and ICC, respectively. The wCV and ICC of cortical thickness were similar across all regions with both 3D MRF and FSPGR. The percent relative difference in cortical thickness between 3D MRF and FSPGR across all regions was 8.0 ± 3.2%. The wCV and ICC of the volume of subcortical structures across all structures were similar between 3D MRF and FSPGR. The percent relative difference in the volume of subcortical structures between 3D MRF and FSPGR across all structures was 7.1 ± 3.6%. 3D MRF measurements of human brain cortical thickness and subcortical volumes are highly repeatable, and consistent with measurements taken on conventional 3D T1‐weighted images. A slight, consistent bias was evident between the two, and thus careful attention is required when combining data from MRF and conventional acquisitions. Three‐dimensional (3D) Magnetic resonance fingerprinting (MRF) permits whole‐brain volumetric quantification of T1 and T2 relaxation values, potentially replacing conventional T1‐weighted structural imaging for common brain imaging analysis. The aim of this study was to evaluate the repeatability and reproducibility of 3D MRF in evaluating brain cortical thickness and subcortical volumetric analysis. 3D MRF measurements of human brain cortical thickness and subcortical volumes are highly repeatable, and consistent with measurements taken on conventional 3D T1‐weighted images. |
Databáze: | OpenAIRE |
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