Repeatability and reproducibility of human brain morphometry using three‐dimensional magnetic resonance fingerprinting

Autor: Matteo Cencini, Akifumi Hagiwara, Shohei Fujita, Shigeki Aoki, Koji Kamagata, Naoyuki Takei, Guido Buonincontri, Issei Fukunaga, Masaaki Hori, Rolf F. Schulte, Wataru Uchida, Osamu Abe
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Adult
Male
Relaxometry
Materials science
Intraclass correlation
Coefficient of variation
relaxometry
050105 experimental psychology
03 medical and health sciences
Young Adult
0302 clinical medicine
Technical Report
Imaging
Three-Dimensional
Neuroimaging
medicine
Brain segmentation
Humans
0501 psychology and cognitive sciences
Radiology
Nuclear Medicine and imaging
repeatability
reproducibility
Aged
Reproducibility
Radiological and Ultrasound Technology
medicine.diagnostic_test
05 social sciences
Brain
Reproducibility of Results
Magnetic resonance imaging
Repeatability
Organ Size
Middle Aged
Brain Cortical Thickness
Magnetic Resonance Imaging
Neurology
human brain imaging
Female
Neurology (clinical)
magnetic resonance fingerprinting
Anatomy
030217 neurology & neurosurgery
morphometry
Biomedical engineering
Zdroj: Human Brain Mapping
ISSN: 1097-0193
1065-9471
Popis: Three‐dimensional (3D) Magnetic resonance fingerprinting (MRF) permits whole‐brain volumetric quantification of T1 and T2 relaxation values, potentially replacing conventional T1‐weighted structural imaging for common brain imaging analysis. The aim of this study was to evaluate the repeatability and reproducibility of 3D MRF in evaluating brain cortical thickness and subcortical volumetric analysis in healthy volunteers using conventional 3D T1‐weighted images as a reference standard. Scan‐rescan tests of both 3D MRF and conventional 3D fast spoiled gradient recalled echo (FSPGR) were performed. For each sequence, the regional cortical thickness and volume of the subcortical structures were measured using standard automatic brain segmentation software. Repeatability and reproducibility were assessed using the within‐subject coefficient of variation (wCV), intraclass correlation coefficient (ICC), and mean percent difference and ICC, respectively. The wCV and ICC of cortical thickness were similar across all regions with both 3D MRF and FSPGR. The percent relative difference in cortical thickness between 3D MRF and FSPGR across all regions was 8.0 ± 3.2%. The wCV and ICC of the volume of subcortical structures across all structures were similar between 3D MRF and FSPGR. The percent relative difference in the volume of subcortical structures between 3D MRF and FSPGR across all structures was 7.1 ± 3.6%. 3D MRF measurements of human brain cortical thickness and subcortical volumes are highly repeatable, and consistent with measurements taken on conventional 3D T1‐weighted images. A slight, consistent bias was evident between the two, and thus careful attention is required when combining data from MRF and conventional acquisitions.
Three‐dimensional (3D) Magnetic resonance fingerprinting (MRF) permits whole‐brain volumetric quantification of T1 and T2 relaxation values, potentially replacing conventional T1‐weighted structural imaging for common brain imaging analysis. The aim of this study was to evaluate the repeatability and reproducibility of 3D MRF in evaluating brain cortical thickness and subcortical volumetric analysis. 3D MRF measurements of human brain cortical thickness and subcortical volumes are highly repeatable, and consistent with measurements taken on conventional 3D T1‐weighted images.
Databáze: OpenAIRE
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