Ultrastructural aspects of the histogenesis of diffuse and localized mesothelioma
| Autor: | Irving Dardick, A. C. Ritchie, A. W. P. Van Nostrand, J. R. Srigley, McCaughey Wt |
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| Rok vydání: | 1984 |
| Předmět: |
Mesothelioma
Pathology medicine.medical_specialty Stromal cell Pleural Neoplasms Histogenesis Biology Cell junction Pathology and Forensic Medicine law.invention law medicine Humans neoplasms Molecular Biology Process (anatomy) Microvilli Cell Biology General Medicine respiratory system medicine.disease respiratory tract diseases Microscopy Electron medicine.anatomical_structure Intercellular Junctions Ultrastructure Basal lamina Electron microscope |
| Zdroj: | Virchows Archiv. A, Pathological anatomy and histopathology. 402(4) |
| ISSN: | 0174-7398 |
| Popis: | During an ultrastructural review of 30 diffuse and 10 localized mesotheliomas, it was apparent that some micrographs showed various stages in the developmental processes involved in the formation of histological patterns in diffuse mesotheliomas and a histogenetic link between diffuse and localized mesotheliomas. Cells in the stromal or sarcomatous regions of diffuse mesothelioma often show varying degrees of mesothelial differentiation and a gradual transition to cells with typical mesothelial characteristics that organize into structures recapitulating the surface layer of serosal membranes. Tumor cells in localized mesotheliomas had many similarities to the “stromal” cells in the diffuse counterpart including intercellular junctions, rare microvilli and occasional foci of basal lamina. It is postulated that diffuse and localized mesotheliomas share a common histogenetic origin as a result of neoplastic induction of specialized submesothelial cells. In this concept, tumor cells in diffuse mesotheliomas reflect stages in the differentiation and organization of normal serosal membranes and localized mesotheliomas mirror the earliest phases of this process. |
| Databáze: | OpenAIRE |
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