CD8 memory T cells: cross-reactivity and heterologous immunity
| Autor: | Claudia Calcagno, Roberto Puzone, Michael A. Brehm, Raymond M. Welsh, Liisa K. Selin, Sung-Kwon Kim, Markus Cornberg, Dario Ghersi, Franco Celada |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Memory attrition
Isoantigens RSV respiratory syncytical virus VSV vesicular stomatitis virus Cross-reactive Immunology LCMV lymphocytic choriomeningitis virus Heterologous Memory T cell CD8-Positive T-Lymphocytes Cross Reactions Biology Article Heterologous immunity Immune system EBV Epstein Barr virus Immunity medicine Animals Immunology and Allergy VV vaccinia virus MCMV murine cytomegalovirus NP nucleoprotein Mathematical Computing CFSE 5-(and -6-)-carboxyfluorescein diacetate succinimidyl ester PV Pichinde virus APC antigen presenting cells Immunization Passive Memory pool Acquired immune system TdT terminal deoxynucleotidyl transferase Transplantation medicine.anatomical_structure Virus Diseases Allo-reactive Immunologic Memory CD8 |
| Zdroj: | Seminars in Immunology |
| ISSN: | 1044-5323 |
| Popis: | Virus-specific memory T cell populations demonstrate plasticity in antigen recognition and in their ability to accommodate new memory T cell populations. The degeneracy of T cell antigen recognition and the flexibility of diverse antigen-specific repertoires allow the host to respond to a multitude of pathogens while accommodating these numerous large memory pools in a finite immune system. These cross-reactive memory T cells can be employed in immune responses and mediate protective immunity, but they can also induce life-threatening immunopathology or impede transplantation tolerance and graft survival. Here we discuss examples of altered viral pathogenesis occurring as a consequence of heterologous T cell immunity and propose models for the maintenance of a dynamic pool of memory cells. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect