The inflammatory response to bone infection – a review based on animal models and human patients

Autor:	Henrik Jeldtoft Jensen, Kerstin Skovgaard, Freja Lea Lüthje, Louise Kruse Jensen
Rok vydání:	2020
Předmět:	0301 basic medicine Microbiology (medical) Prosthetic joint infection Staphylococcus aureus Prosthesis-Related Infections Inflammation medicine.disease_cause Bone and Bones Bone resorption Pathology and Forensic Medicine Bone remodeling Bone Infection 03 medical and health sciences 0302 clinical medicine Immune system In vivo medicine Animals Humans Immunology and Allergy Immune response business.industry Osteomyelitis General Medicine Staphylococcal Infections medicine.disease 3. Good health Disease Models Animal 030104 developmental biology 030220 oncology & carcinogenesis Immunology Cytokines medicine.symptom business
Zdroj:	APMIS Lüthje, F L, Jensen, L K, Elvang Jensen, H & Skovgaard, K 2020, ' The inflammatory response to bone infection A review based on animal models and human patients ', APMIS, vol. 128, no. 4, pp. 275-286 . https://doi.org/10.1111/apm.13027 Lüthje, F L, Jensen, L K, Jensen, H E & Skovgaard, K 2020, ' The inflammatory response to bone infection – a review based on animal models and human patients ', APMIS, vol. 128, no. 4, pp. 275-286 . https://doi.org/10.1111/apm.13027
ISSN:	1600-0463 0903-4641
Popis:	Bone infections are difficult to diagnose and treat, especially when a prosthetic joint replacement or implant is involved. Bone loss is a major complication of osteomyelitis, but the mechanism behind has mainly been investigated in cell cultures and has not been confirmed in human settings. Inflammation is important in initiating an appropriate immune response to invading pathogens. However, many of the signaling molecules used by the immune system can also modulate bone remodeling and contribute to bone resorption during osteomyelitis. Our current knowledge of the inflammatory response relies heavily on animal models as research based on human samples is scarce. Staphylococcus aureus is one of the most common causes of bone infections and is the pathogen of choice in animal models. The regulation of inflammatory genes during prosthetic joint infections and implant-associated osteomyelitis has only been studied in rodent models. It is important to consider the validity of an animal model when results are extrapolated to humans, and both bone composition and the immune system of pigs has been shown to be more similar to humans, than to rodents. Here in vivo studies on the inflammatory response to prosthetic joint infections and implant-associated osteomyelitis are reviewed.
Databáze:	OpenAIRE
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