Otx2, Gbx2 and Fgf8 interact to position and maintain a mid-hindbrain organizer
| Autor: | Alexandra L. Joyner, Aimin Liu, Sandrine Millet |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
animal structures
Fibroblast Growth Factor 8 Hindbrain Nerve Tissue Proteins Biology Otx Transcription Factors Feedback Midbrain Mice FGF8 Prosencephalon Mesencephalon Cerebellum Proto-Oncogene Proteins Animals GBX2 Body Patterning Embryonic Induction Homeodomain Proteins Organizers Embryonic Brain Gene Expression Regulation Developmental Cell Biology Anatomy Zebrafish Proteins Transplantation Fibroblast Growth Factors Rhombencephalon Wnt Proteins nervous system embryonic structures Trans-Activators Neuroscience |
| Zdroj: | Current opinion in cell biology. 12(6) |
| ISSN: | 0955-0674 |
| Popis: | A decade ago, chick-quail transplantation studies demonstrated that the junction between the midbrain and hindbrain has the properties of an organizing center capable of patterning the midbrain and cerebellum. Many of the genes that function to pattern these tissues have been identified and extensively studied. Recent experiments have shown that Otx2, Gbx2 and Fgf8 genes play a major role in the positioning and functioning of this organizing center. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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