Vitamin B12 deficiency and altered one-carbon metabolites in early pregnancy is associated with maternal obesity and dyslipidaemia
| Autor: | Yonas Ghebremichael Weldeselassie, Catherine Wood, Ilona Goljan, Theresia H. Mina, Craig Webster, Rebecca M. Reynolds, Antonysunil Adaikalakoteswari, Ponnusamy Saravanan |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
0301 basic medicine Offspring Metabolic disorders lcsh:Medicine Physiology 030209 endocrinology & metabolism Article Cohort Studies Obesity Maternal 03 medical and health sciences 0302 clinical medicine Insulin resistance Pregnancy medicine Humans Nutrition disorders Vitamin B12 lcsh:Science Dyslipidemias 030109 nutrition & dietetics Multidisciplinary business.industry lcsh:R Vitamin B 12 Deficiency Prognosis medicine.disease Micronutrient Carbon Pregnancy Complications Gestational diabetes Cohort lcsh:Q Female RG business RC Cohort study |
| Zdroj: | Adaikalakoteswari, A, Wood, C, Mina, T, Webster, C, Goljan, I, Weldeselassie, Y, Reynolds, R & Saravanan, P 2020, ' Vitamin B12 deficiency and altered one-carbon metabolites in early pregnancy is associated with maternal obesity and dyslipidaemia ', Scientific Reports . https://doi.org/10.1038/s41598-020-68344-0 Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020) |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-020-68344-0 |
| Popis: | Vitamin B12 (B12) is a micronutrient essential for one-carbon (1C) metabolism. B12 deficiency disturbs the 1C cycle and alters DNA methylation which is vital for most metabolic processes. Studies show that B12 deficiency may be associated with obesity, insulin resistance and gestational diabetes; and with obesity in child-bearing women. We therefore hypothesised that the associations between B12 deficiency, BMI and the metabolic risk could be mediated through altered 1C metabolites in early pregnancy. We explored these associations in two different early pregnancy cohorts in the UK (cohort 1; n = 244 and cohort 2; n = 60) with anthropometric data at 10–12 weeks and plasma/serum sampling at 16–18 weeks. B12, folate, total homocysteine (tHcy), methionine, MMA, metabolites of 1C metabolism (SAM, SAH) and anthropometry were measured. B12 deficiency ( |
| Databáze: | OpenAIRE |
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