Comparative pharmacokinetic and photodynamic studies with zinc(II) phthalocyanine in hamsters bearing an induced or transplanted rhabdomyosarcoma
| Autor: | D. Hadjiolov, Maria Shopova, Giulio Jori, K. Spirov, Fernanda Ricchelli, A. Milev, Vanya Mantareva, K.K. Krastev |
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| Rok vydání: | 1992 |
| Předmět: |
Radiation-Sensitizing Agents
Indoles Time Factors medicine.medical_treatment Biophysics chemistry.chemical_element Hamster Photodynamic therapy Zinc Isoindoles chemistry.chemical_compound Pharmacokinetics Cricetinae Rhabdomyosarcoma Organometallic Compounds medicine Animals Radiology Nuclear Medicine and imaging Photosensitizer Liposome Radiation Mesocricetus Radiological and Ultrasound Technology Lasers medicine.disease Photochemotherapy chemistry Zinc Compounds Liposomes Immunology Cancer research Phthalocyanine |
| Zdroj: | Journal of Photochemistry and Photobiology B: Biology. 16:83-89 |
| ISSN: | 1011-1344 |
| Popis: | Comparative pharmacokinetic studies in hamsters bearing an induced or first-generation transplanted rhabdomyosarcoma that were injected with liposome-incorporated zinc(II) phthalocyanine (ZnPc) show a higher drug concentration in the induced tumour. The selectivity of tumour targeting is underlined by the fact that, 24 h after injection, larger amounts of ZnPc are found in the tumour than in the liver. Photodynamic therapy investigations were carried out using 673 nm light from an argon-dye laser. On the basis of different assessment criteria (changes in mean tumour diameter with time, tumour mass regression, survival time of the treated groups of animals, and histological determination of the necrotic tissue) the photosensitizing effect of ZnPc appears to be comparable for both kinds of tumour in spite of the higher uptake of photosensitizer by the induced tumour. |
| Databáze: | OpenAIRE |
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