Immunity to challenge in volunteers vaccinated with an inactivated current or earlier strain of influenza A(H3N2)
| Autor: | H. E. Larson, D. A. J. Tyrrell, Geoffrey C. Schild, C. H. Bowker, Christopher W. Potter |
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| Jazyk: | angličtina |
| Rok vydání: | 1978 |
| Předmět: |
Serotype
Hemagglutination Immunology Orthomyxoviridae Antibodies Viral Microbiology Immunity Influenza Human Medicine Humans Attenuated vaccine biology Inoculation business.industry Vaccination Public Health Environmental and Occupational Health biology.organism_classification Virology Immunity Active Influenza Vaccines biology.protein Antibody business Research Article |
| Popis: | SUMMARYVolunteers were inoculated with vaccine made from the 30c mutant, A/Port Chalmers/73 or B/Hong/8/73. Preliminary experiments showed that the 30c strain was antigenically quite close to A/HK/8/68. Volunteers given 30c developed haemagglutination inhibiting antibodies against the ‘current’ 1973 serotypes (as well as to the vaccine virus) but the titres were less than those after the A/PC/73 vaccine. Volunteers were then challenged with a live attenuated virus, WRL 105, with A/Finland/4/74 antigens, by intranasal inoculation. The rates of infection were 43% after B/Hong Kong/8/73, 20% after 30c and 5% after A/PC/73. This indicated that the 30c gave some protection but the vaccine prepared from the current strain gave more. |
| Databáze: | OpenAIRE |
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