Characteristic Features of Protein Interaction with Single- and Double-Stranded RNA
| Autor: | Alexey D. Nikulin |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
Models Molecular Protein Folding Base Sequence Spatial structure Amino Acid Motifs RNA Zinc Fingers General Medicine Double stranded rna Biochemistry Protein Structure Secondary chemistry Protein Domains Ribosomal protein RNA-Protein Interaction Bioorganic chemistry Humans Nucleic Acid Conformation Nucleotide Single-Stranded RNA Protein Binding RNA Double-Stranded |
| Zdroj: | Biochemistry. Biokhimiia. 86(8) |
| ISSN: | 1608-3040 |
| Popis: | The review discusses differences between the specific protein interactions with single- and double-stranded RNA molecules using the data on the structure of RNA-protein complexes. Proteins interacting with the single-stranded RNAs form contacts with RNA bases, which ensures recognition of specific nucleotide sequences. Formation of such contacts with the double-stranded RNAs is hindered, so that the proteins recognize unique conformations of the RNA spatial structure and interact mainly with the RNA sugar-phosphate backbone. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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