Risk and Prognostic Factors for Rupture of Intracranial Aneurysms During Endovascular Embolization
| Autor: | Chao Jiang, Qinglin Liu, Gang Li, Chen Wang, Deheng Luan, Jie Han |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Subarachnoid hemorrhage medicine.medical_treatment Aneurysm Ruptured 03 medical and health sciences 0302 clinical medicine Cerebral vasospasm Aneurysm Risk Factors medicine Humans cardiovascular diseases Embolization Aged Retrospective Studies Univariate analysis business.industry Endovascular Procedures Vasospasm Intracranial Aneurysm Nomogram Middle Aged medicine.disease Prognosis Embolization Therapeutic Hydrocephalus Surgery Treatment Outcome 030220 oncology & carcinogenesis Female Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | World neurosurgery. 129 |
| ISSN: | 1878-8769 |
| Popis: | Intraoperative aneurysm rupture (IPR) always results in a poor prognosis for the patient. However, the risk factors of IPR are unclear. In this article, the risk factors are explored, a nomogram model for predicting IPR is established, and the prognostic factors for patients with IPR are analyzed.A total of 549 patients with aneurysm, which were embolized from September 2011 to September 2015, were enrolled for analysis. Univariate and multivariate logistic regression were performed to explore the risk factors for IPR, and a nomogram was established. A nonparametric Mann-Whitney U test was performed to analyze prognostic factors for patients with IPR.Twenty-one patients (4.4%) experienced IPR. In univariate analysis, Hunt-Hess grade (P = 0.002), time from hospitalization to treatment (P = 0.08) and subarachnoid hemorrhage (SAH) to treatment (P = 0.08), aneurysm neck (P = 0.08), assistive technique (P = 0.03), and intraoperative cerebral vasospasm (P0.001) were significantly associated with IPR. In multivariate analysis, Hunt-Hess grade (odds ratio [OR], 8.177; 95% confidence interval [CI], 1.714-39.012; P = 0.008), aneurysm neck (OR, 5.629; 95% CI, 1.149-27.575; P = 0.033), assistive technique (OR, 1.393; 95% CI, 0.961-2.018; P = 0.080), and intraoperative cerebral vasospasm (OR, 4.280; 95% CI, 1.081-16.947; P = 0.038) were independent risk factors for IPR. Hydrocephalus (P = 0.069), history of SAH (P = 0.10), ≥2 SAH (P = 0.051), location of aneurysm (P = 0.09), and number of aneurysms (P = 0.025) were associated with the bad outcome.Hunt-Hess grading, aneurysm neck, intraoperative assistive technology, and vasospasm were independent risk factors for IPR. Hydrocephalus requiring surgical intervention, times of rupture, location of aneurysm, and the number of aneurysms were relevant to the prognosis of patients. |
| Databáze: | OpenAIRE |
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