Involvement of MarR and YedS in carbapenem resistance in a clinical isolate of Escherichia coli from China
| Autor: | Qiwen Yang, Douglas M. Warner, Yingchun Xu, Stuart B. Levy, Valérie Duval, Minjun Chen |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Small RNA
China Molecular Sequence Data Repressor Biology medicine.disease_cause Bacterial genetics Microbiology Mechanisms of Resistance medicine Escherichia coli Pharmacology (medical) Gene Regulator gene Pharmacology Regulation of gene expression Genetics Escherichia coli Proteins Gene Expression Regulation Bacterial biochemical phenomena metabolism and nutrition Repressor Proteins Infectious Diseases Carbapenems Porin bacteria Electrophoresis Polyacrylamide Gel |
| Zdroj: | Antimicrobial agents and chemotherapy. 57(4) |
| ISSN: | 1098-6596 |
| Popis: | A carbapenem-resistant clinical isolate of Escherichia coli , which lacked OmpF and OmpC porins, carried a marR mutation and expressed a functional yedS , a normally nontranslated gene. MarR and YedS are described here as having effects on the ability of this strain to resist carbapenems. Additionally, expression of YedS was regulated by the small RNA MicF in a MarA-dependent way. These findings illustrate how broadly bacteria can mutate within a selective clinical setting, in this case, resistance to carbapenems, by altering three porin genes and one regulatory gene. |
| Databáze: | OpenAIRE |
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