5-HT2A and 5-HT2C/5-HT1B receptors are differentially involved in alcohol preference and consummatory behavior in cAA rats
| Autor: | René De Beun, Rudy Schreiber, Jean De Vry, S. Maurel |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Agonist
Male medicine.medical_specialty Alcohol Drinking medicine.drug_class Clinical Biochemistry Ritanserin Toxicology Biochemistry Behavioral Neuroscience chemistry.chemical_compound Internal medicine medicine Receptor Serotonin 5-HT2C Animals Receptor Serotonin 5-HT2A Receptor Biological Psychiatry 5-HT receptor Pharmacology Analysis of Variance Ethanol Chemistry Rats Inbred Strains Receptor antagonist Rats Serotonin Receptor Agonists Endocrinology Mechanism of action Receptors Serotonin Receptor Serotonin 5-HT1B Female Serotonin Serotonin Antagonists medicine.symptom medicine.drug |
| Zdroj: | Pharmacology, biochemistry, and behavior. 62(1) |
| ISSN: | 0091-3057 |
| Popis: | The present study aimed to investigate the role of serotonin 5-HT2A and 5-HT2C receptors in the control of alcohol preference and consummatory behavior in alcohol-preferring cAA rats. Effects of the 5-HT(2A/2C) receptor agonist, DOI, the 5-HT(2C/1B) receptor agonist, mCPP, the 5-HT(2A/2C) receptor antagonist, ritanserin, and the 5-HT2A receptor antagonist, MDL 100,907, on ethanol (EtOH, 10% v/v) preference and intake, as well as total fluid and food intake were evaluated in a 12-h limited-access two-bottle paradigm. DOI (0.3-3 mg/kg, i.p.) reduced EtOH intake and preference, but not total fluid or food intake; whereas mCPP (1-10 mg/kg, s.c.) reduced EtOH, total fluid, and food intake. Therefore, it is concluded that DOI induces a specific and selective antialcohol effect, whereas mCPP rather induces a general suppressive effect on consummatory behavior. Ritanserin (1-10 mg/kg, i.p.) did not affect EtOH intake and preference, nor total fluid and food consumption. MDL 100,907 (0.1-1 mg/kg, i.p.) induced only a small reduction of food intake at the highest dose tested. Pretreatment with ritanserin (3 mg/kg, i.p.) and MDL 100,907 (0.3 mg/kg, i.p.) blocked the effects of DOI (3 mg/kg, i.p.), but not those of mCPP (10 mg/kg, i.p.). It is suggested that activation of 5-HT2C and/or 5-HT1B receptors results in a general decrease of consummatory behavior, whereas activation of 5-HT2A receptors selectively decreases EtOH intake and preference, as assessed in the cAA rat model of alcoholism. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect