Efflux Pumps Are Involved in the Defense of Gram-Negative Bacteria against the Natural Products Isobavachalcone and Diospyrone
| Autor: | Victor Kuete, Bonaventure T. Ngadjui, Bathelemy Ngameni, Jean-Marie Pagès, Jean Gustave Tangmouo, Sandrine Alibert-Franco, Jean-Michel Bolla |
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| Přispěvatelé: | Transporteurs membranaires, chimioresistance et drug-design (TMCD2), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Biochemistry, Université de Dschang, Faculty of Medicine and Biomedical Science, University of Yaoundé [Cameroun], Faculty of Science, Alibert, Sandrine |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Gram-negative bacteria
[CHIM.THER] Chemical Sciences/Medicinal Chemistry [CHIM.THER]Chemical Sciences/Medicinal Chemistry Microbiology 03 medical and health sciences chemistry.chemical_compound Chalcones Bacterial Proteins Mechanisms of Resistance Drug Discovery Drug Resistance Bacterial Enterobacter cloacae Gram-Negative Bacteria Escherichia coli Pharmacology (medical) 030304 developmental biology Plant Proteins Pharmacology 0303 health sciences Natural product biology 030306 microbiology Membrane Transport Proteins Enterobacter aerogenes Membrane transport Diospyros biology.organism_classification [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology In vitro Drug Resistance Multiple 3. Good health Klebsiella pneumoniae Infectious Diseases chemistry Mic values [SDV.SP.PHARMA] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology Pseudomonas aeruginosa [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology Efflux [SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology Antibacterial activity Carrier Proteins Bacteria |
| Zdroj: | Antimicrobial Agents and Chemotherapy Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2010, 54 (5), pp.1749-1752. ⟨10.1128/AAC.01533-09⟩ |
| ISSN: | 0066-4804 1098-6596 |
| DOI: | 10.1128/AAC.01533-09⟩ |
| Popis: | The activities of two naturally occurring compounds, isobavachalcone and diospyrone, against documented strains and multidrug-resistant (MDR) Gram-negative bacterial isolates were evaluated. The results indicated that the two compounds exhibited intrinsic antibacterial activity against several Gram-negative bacteria, and their activities were significantly improved in the presence of an efflux pump inhibitor (MIC values decreased to below 10 μg/ml). In addition, the activities of isobavachalcone and diospyrone against various strains exhibiting deletions of the major efflux pump components (AcrAB, TolC) were significantly increased. The overall results indicate that isobavachalcone and diospyrone could be candidates for the development of new drugs against MDR strains and that their use in combination with efflux pump inhibitors reinforces their activity. |
| Databáze: | OpenAIRE |
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