The acute effect of methylphenidate on cerebral blood flow in boys with attention-deficit/hyperactivity disorder
| Autor: | Daniel D. Langleben, Flávio Kapczinski, Luis Augusto Rohde, Carla R. Ketzer, Paul D. Acton, Maria Alice de Mattos Pimenta Parente, Renato D. Cunha, Claudia Maciel Szobot |
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| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Posterior parietal cortex Hemodynamics Statistical parametric mapping Placebo Placebos Double-Blind Method Parietal Lobe mental disorders medicine Humans Attention deficit hyperactivity disorder Radiology Nuclear Medicine and imaging Cysteine Child Radionuclide Imaging Psychiatry business.industry Methylphenidate Therapeutic effect Organotechnetium Compounds General Medicine medicine.disease Cerebral blood flow Attention Deficit Disorder with Hyperactivity Cerebrovascular Circulation Anesthesia Radiopharmaceuticals business human activities Blood Flow Velocity medicine.drug |
| Zdroj: | European Journal of Nuclear Medicine and Molecular Imaging. 30:423-426 |
| ISSN: | 1619-7089 1619-7070 |
| DOI: | 10.1007/s00259-002-1082-0 |
| Popis: | Methylphenidate (MPH) is the most common- ly prescribed treatment for attention-deficit/hyperactivity disorder (ADHD). The therapeutic mechanisms of MPH are not, however, fully understood. We studied the ef- fects of MPH on brain activity in male children and ado- lescents with ADHD, using the blood flow radiotracer technetium-99m ethyl cysteinate dimer ( 99m Tc-ECD) and single-photon emission tomography (SPET) . The study was randomized, double blind, and placebo controlled (MPH group, n=19; placebo group, n=17), Radiotracer was administered during the performance of the Contin- uous Performance Test and before and after 4 days of MPH treatment. Statistical parametric mapping (SPM99) analysis showed a significant reduction in regional cere- bral blood flow in the left parietal region in the MPH group compared with the placebo group (P |
| Databáze: | OpenAIRE |
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