DNA-Inspired Strand-Exchange for Switchable PMMA-Based Supramolecular Morphologies
| Autor: | David J. Lunn, Abigail S. Knight, Youli Li, Bas G. P. van Ravensteijn, Greg G. Qiao, Raghida Bou Zerdan, Craig J. Hawker, Phillip Kohl, Allison Abdilla, Jing M. Ren |
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| Rok vydání: | 2019 |
| Předmět: |
Models
Molecular Supramolecular chemistry Nanoparticle macromolecular substances Polyethylene glycol 010402 general chemistry 01 natural sciences Biochemistry Micelle Catalysis law.invention chemistry.chemical_compound Colloid and Surface Chemistry law Copolymer Polymethyl Methacrylate Methyl methacrylate Crystallization Chemistry technology industry and agriculture Stereoisomerism DNA General Chemistry 0104 chemical sciences Chemical engineering Helix Nucleic Acid Conformation |
| Zdroj: | Journal of the American Chemical Society. 141:2630-2635 |
| ISSN: | 1520-5126 0002-7863 |
| Popis: | Inspired by nanotechnologies based on DNA strand displacement, herein we demonstrate that synthetic helical strand exchange can be achieved through tuning of poly(methyl methacrylate) (PMMA) triple-helix stereocomplexes. To evaluate the utility and robustness of helical strand exchange, stereoregular PMMA/polyethylene glycol (PEG) block copolymers capable of undergoing crystallization driven self-assembly via stereocomplex formation were prepared. Micelles with spherical or wormlike morphologies were formed by varying the molecular weight composition of the assembling components. Significantly, PMMA strand exchange was demonstrated and utilized to reversibly switch the micelles between different morphologies. This concept of strand exchange with PMMA-based triple-helix stereocomplexes offers new opportunities to program dynamic behaviors of polymeric materials, leading to scalable synthesis of "smart" nanosystems. |
| Databáze: | OpenAIRE |
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