Serine protease HtrA1 is developmentally regulated in trophoblast and uterine decidual cells during placental formation in the mouse
| Autor: | Lois A. Salamonsen, Ying Li, Guiying Nie |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Proteases
Placenta Biology Mice Decidua Capsularis Pregnancy medicine Animals Decidual cells RNA Messenger reproductive and urinary physiology Serine Endopeptidases Uterus Decidua Gene Expression Regulation Developmental Placentation Trophoblast Serine Protease HTRA1 High-Temperature Requirement A Serine Peptidase 1 Trophoblasts Cell biology medicine.anatomical_structure embryonic structures Immunology Female Developmental Biology |
| Zdroj: | Developmental Dynamics. 233:1102-1109 |
| ISSN: | 1097-0177 1058-8388 |
| DOI: | 10.1002/dvdy.20399 |
| Popis: | Development of a hemochorial placenta involves trophoblast proliferation, differentiation, and invasion into the uterus to promote blood flow to the embryo. Trophoblast invasion is tightly controlled by expression of specific proteases in the trophoblast and highly coordinated activities in the uterus. One uterine event essential for placentation is the developmentally regulated formation and regression of the decidua. In mice, decidual regression takes place in a temporal- and spatial-specific manner that is coordinated with placental development. In this study, we identified that the serine protease HtrA1 (high temperature requirement factor A1) was specifically expressed in differentiated trophoblast cells, especially the giant cells, during the early stages of placental development. A high level of HtrA1 expression was also detected in decidua capsularis specifically at the decidual-trophoblast interface where active involution occurs. Thus, we have identified a previously unknown role for HtrA1 as a protease potentially important for trophoblast differentiation/invasion and uterine decidual regression during placental development. |
| Databáze: | OpenAIRE |
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