White matter correlates of slowed information processing speed in unimpaired multiple sclerosis patients with young age onset
| Autor: | Yilin Liu, Lev Bangiyev, Maria Andrea Parra Corral, Sindhuja T. Govindarajan, Lauren Krupp, Timothy Q. Duong, Leigh Charvet |
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| Rok vydání: | 2020 |
| Předmět: |
Elementary cognitive task
medicine.medical_specialty Multiple Sclerosis Cognitive Neuroscience Audiology Corpus callosum 050105 experimental psychology White matter 03 medical and health sciences Behavioral Neuroscience Cellular and Molecular Neuroscience Cognition 0302 clinical medicine Fasciculus Fractional anisotropy medicine Humans 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging Child biology business.industry Multiple sclerosis 05 social sciences Neuropsychology medicine.disease biology.organism_classification Magnetic Resonance Imaging White Matter Psychiatry and Mental health Diffusion Tensor Imaging medicine.anatomical_structure Neurology Anisotropy Neurology (clinical) business 030217 neurology & neurosurgery Diffusion MRI |
| Zdroj: | Brain Imaging and Behavior. 15:1460-1468 |
| ISSN: | 1931-7565 1931-7557 |
| Popis: | Slowed information processing speed is among the earliest markers of cognitive impairment in multiple sclerosis (MS) and has been associated with white matter (WM) structural integrity. Localization of WM tracts associated with slowing, but not significant impairment, on specific cognitive tasks in pediatric and young age onset MS can facilitate early and effective therapeutic intervention. Diffusion tensor imaging data were collected on 25 MS patients and 24 controls who also underwent the Symbol Digit Modalities Test (SDMT) and the computer-based Cogstate simple and choice reaction time tests. Fractional anisotropy (FA), mean (MD), radial (RD) and axial (AD) diffusivities were correlated voxel-wise with processing speed measures. All DTI metrics of several white matter tracts were significantly different between groups (p |
| Databáze: | OpenAIRE |
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