Influence of vaccination on adverse health outcomes after SARS‐CoV‐2 infection among individuals with alcohol use disorder: a population‐based study

Autor: Gro Askgaard, Merete Osler, Thomas Munk Laursen, Carsten Hjorthøj, Michael E. Benros, Steen Ethelberg, Kåre Mølbak, Merete Nordentoft, Sandra Feodor Nilsson
Rok vydání: 2023
Předmět:
Zdroj: Askgaard, G, Osler, M, Laursen, T M, Hjorthøj, C, Benros, M E, Ethelberg, S, Mølbak, K, Nordentoft, M & Nilsson, S F 2023, ' Influence of vaccination on adverse health outcomes after SARS-CoV-2 infection among individuals with alcohol use disorder : a population-based study ', Addiction, vol. 118, no. 8 . https://doi.org/10.1111/add.16196
Askgaard, G, Osler, M, Laursen, T M, Hjorthøj, C, Benros, M E, Ethelberg, S, Mølbak, K, Nordentoft, M & Nilsson, S F 2023, ' Influence of vaccination on adverse health outcomes after SARS-CoV-2 infection among individuals with alcohol use disorder : a population-based study ', Addiction, vol. 118, no. 8, pp. 1482-1492 . https://doi.org/10.1111/add.16196
ISSN: 1360-0443
0965-2140
Popis: Background and Aims: Alcohol use disorders (AUD) have not been included in the priority groups for early vaccine against SARS-CoV-2. We aimed to determine adverse outcomes after SARS-CoV-2 infection among individuals with AUD and how this is modified by vaccination. Design, Setting and Participants: This was a registry-based cohort study carried out in Denmark, 27 February 2020 to 15 October 2021, comprising 2157 individuals with AUD and 237 541 without AUD who had had a polymerase chain reaction (PCR)-confirmed SARS-CoV-2 infection during the study period. Measurements: The association of AUD with the absolute and relative risk of hospitalization, intensive care and 60-day mortality after SARS-CoV-2 infection and of all-cause mortality throughout the follow-up period were measured. Potential interactions with SARS-CoV-2 vaccination, education and sex were explored in stratified analyses and tested by including interaction terms and using likelihood ratio tests. Findings: Individuals with AUD had an increased absolute and relative risk of adverse outcomes, including hospitalization [incidence rate ratio (IRR) = 1.72, 95% confidence interval (CI) = 1.51–1.95], intensive care (IRR = 1.47, 95% CI = 1.07–2.02) and 60-day mortality [mortality rate ratio (MRR) = 2.35, 95% CI = 1.94–2.85] compared with SARS-CoV-2-positive individuals without AUD. Irrespective of AUD, highest risks of these adverse health outcomes were observed for individuals not vaccinated against SARS-CoV-2 infection, for individuals of low educational level and in males. However, for all-cause mortality throughout the follow-up period, SARS-CoV-2 infection showed a lower relative mortality risk increase, whereas being unvaccinated showed a higher relative mortality risk increase, in individuals with AUD than in the reference population without AUD (P of interaction tests < 0.0001). Conclusions: Both alcohol use disorder and being unvaccinated for SARS-CoV-2 appear to be independent risk factors for adverse health outcomes following SARS-CoV-2 infection.
Databáze: OpenAIRE
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