Detection rate of prostate cancer following biopsy among the northern Han Chinese population: a single-center retrospective study of 1022 cases

Autor: Xiao-Qing Sun, Yong Jia, Xin‐hong Zhang, Si-Chuan Hou, Chang-Cun Zhang, Zhao-Xu Liu, Lei-Yi Zhu, Jian-Gang Gao, Yu-Xin Xian
Rok vydání: 2017
Předmět:
Male
Oncology
Prostate biopsy
Biopsy
030232 urology & nephrology
Endosonography
PSA
Prostate cancer
0302 clinical medicine
Prostate
Prevalence
Mass Screening
Early Detection of Cancer
Aged
80 and over
medicine.diagnostic_test
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Prognosis
Retrospective study
Prostate-specific antigen
medicine.anatomical_structure
030220 oncology & carcinogenesis
Adult
China
medicine.medical_specialty
lcsh:Surgery
Urology
lcsh:RC254-282
03 medical and health sciences
Internal medicine
medicine
Humans
Ultrasonography
Interventional
Mass screening
Aged
Neoplasm Staging
Retrospective Studies
business.industry
Research
Detection rate
Prostatic Neoplasms
lcsh:RD1-811
DRE
Rectal examination
Prostate-Specific Antigen
medicine.disease
Transrectal ultrasonography
Surgery
business
Zdroj: World Journal of Surgical Oncology
World Journal of Surgical Oncology, Vol 15, Iss 1, Pp 1-7 (2017)
ISSN: 1477-7819
Popis: Background Prostate cancer is known to have ethnic and regional differences. The study aimed to clinically evaluate the detection rate of prostate cancer on transrectal ultrasonography (TRUS)-guided prostate biopsy and analyze its characteristics among the northern Han Chinese population at a single center. Methods Between October 2009 and September 2016, a total of 1027 Chinese men, who had undergone TRUS-guided prostate biopsy at Qingdao Municipal Hospital, were retrospectively analyzed. Prostate biopsies were performed in the case of an abnormally elevated serum PSA level, and/or abnormal digital rectal examination (DRE) findings, and/or suspicious prostatic imaging findings. Results Of the 1022 men enrolled in the analysis, 438 patients (42.8%) were diagnosed with prostate adenocarcinoma histologically. When serum PSA levels were divided into five subgroups (less than 4.0, 4.0 to 10.0, 10.0 to 20.0, 20.0 to 100.0, and ≥ 100.0 ng/ml), the detection rates of prostate cancer were 12.4, 15.9, 34.1, 66.2, and 93.8%, respectively. With serum PSA levels of 4.0 to 10.0 ng/ml, the cancer detection rates for a normal DRE and a suspect DRE finding were 13.5 and 58.2%, respectively. Accordingly, the cancer detection rates for a normal imaging and a suspect imaging finding were 13.5 and 58.2%, respectively. Besides, a large proportion of the patients were in the clinically advanced stage. Conclusions The present study data reported a relatively higher prostate cancer detection rate of 42.8% and that the majority of the patients presented with clinically advanced prostate cancers within a local clinical urologic practice. An early detection and screening program for prostate cancer is of great need to reduce the burden from this disease among the northern Han Chinese population.
Databáze: OpenAIRE
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