Ursolic acid: An overview on its cytotoxic activities against breast and colorectal cancer cells
| Autor: | Chu Yong Soon, Siu Kuin Wong, Yew Woh Hui, Joash Ban Lee Tan, Eric Wei Chiang Chan |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
Colorectal cancer 0211 other engineering and technologies Antineoplastic Agents Breast Neoplasms 02 engineering and technology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Breast cancer Ursolic acid Triterpene In vivo 021105 building & construction medicine Cytotoxic T cell Animals Humans Cell Proliferation chemistry.chemical_classification Cancer General Medicine medicine.disease In vitro Triterpenes 030205 complementary & alternative medicine chemistry Cancer research Female Colorectal Neoplasms Drugs Chinese Herbal |
| Zdroj: | Journal of integrative medicine. 17(3) |
| ISSN: | 2095-4964 |
| Popis: | Ursolic acid (UA) is a pentacyclic triterpene of the ursane type. As a common chemical constituent among species of the family Lamiaceae, UA possesses a broad spectrum of pharmacological properties. This overview focuses on the anticancer properties of UA against breast cancer (BC) and colorectal cancer (CRC) that are most common among women and men, respectively. In vitro studies have shown that UA inhibited the growth of BC and CRC cell lines through various molecular targets and signaling pathways. There are several in vivo studies on the cytotoxic activity of UA against BC and CRC. UA also inhibits the growth of other types of cancer. Studies on structural modifications of UA have shown that the -OH groups at C3 and at C28 are critical factors influencing the cytotoxic activity of UA and its derivatives. Some needs for future research are suggested. Sources of information were from ScienceDirect, Google Scholar and PubMed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect