Impaired anti-pneumococcal polysaccharide antibody production and invasive pneumococcal infection following heart transplantation
| Autor: | C. Rodríguez-Hernández, J. Rodriguez-Molina, N. Lanio, J. Anguita, Eduardo Fernández-Cruz, Juan Fernández-Yáñez, J. L. Perez, Elizabeth Sarmiento, Javier Carbone, Jesús Palomo |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Time Factors Transplantation Conditioning medicine.medical_treatment Immunology Pneumococcal Infections Meningitis Bacterial Pneumococcal Vaccines Daclizumab Monitoring Immunologic medicine Humans Immunology and Allergy Immunosuppression Therapy Pharmacology Heart transplantation business.industry Polysaccharides Bacterial Vaccination Immunosuppression Middle Aged medicine.disease Transplantation Pneumococcal infections Streptococcus pneumoniae Pneumococcal vaccine Immunoglobulin G Antibody Formation Heart Transplantation Female business Meningitis Immunosuppressive Agents medicine.drug |
| Zdroj: | International Immunopharmacology. 6:2027-2030 |
| ISSN: | 1567-5769 |
| DOI: | 10.1016/j.intimp.2006.09.011 |
| Popis: | An increased risk of invasive pneumococcal infection has been described among adult heart transplant (HT) recipients. Vaccination has been recommended before HT but the appropriate time for revaccination is not known. In a preliminary analysis of a prospective study involving a cohort of 32 HT recipients receiving daclizumab and triple immunosuppresion therapy, a progressive decline in pneumococcal polysaccharide antibody (anti-PPS) levels was observed during the first year after HT. One of the patients who was found to have a decrease in the levels of anti-PPS developed severe pneumococcal meningitis 20 months after HT. Before HT he had received non-conjugated 23-valent pneumococcal vaccine and showed a normal post-immunization anti-PPS production. The data suggest that long-term immunologic monitoring might be useful to recognize impairment of antibody responses under immunosuppressive therapy in HT. |
| Databáze: | OpenAIRE |
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