Ethnic Differences in Out-of-Hospital Fatal Pulmonary Embolism
| Autor: | Tao Wang, Yingying Tang, Stephanie Pack, Mechthild Prinz, Krunal R. Shah, Barbara A. Sampson, Dawei Wang, Sung Yon Um |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Emergency Medical Services Pediatrics medicine.medical_specialty Population White People Young Adult Age Distribution Physiology (medical) Epidemiology Ethnicity medicine Humans Sex Distribution Risk factor education Aged Aged 80 and over education.field_of_study Vascular disease business.industry Incidence Incidence (epidemiology) Hispanic or Latino Venous Thromboembolism Middle Aged medicine.disease Confidence interval Pulmonary embolism Surgery Black or African American Female New York City Pulmonary Embolism Cardiology and Cardiovascular Medicine business Body mass index |
| Zdroj: | Circulation. 123:2219-2225 |
| ISSN: | 1524-4539 0009-7322 |
| Popis: | Background— In-hospital pulmonary embolism (PE) has been extensively studied in large populations; however, out-of-hospital fatal PE studies are rare. Here, we systematically evaluated a large number of decedents who suffered fatal PE outside of hospitals and were subsequently investigated by the New York City Office of Chief Medical Examiner. Methods and Results— A total of 578 consecutive out-of-hospital fatal PE cases were analyzed. All underwent autopsy, toxicology, microbiology, and genetic testing. Incidence rates and baseline characteristics were analyzed. Race-adjusted incidence rates of out-of-hospital fatal PE (per 100 000 people per year) were as follows: blacks, 3.73 (95% confidence interval, 3.31 to 4.11); whites, 1.15 (95% confidence interval, 0.96 to 1.33); and Hispanics, 0.93 (95% confidence interval, 0.72 to 1.10). Overall, obesity (body mass index ≥30 kg/m 2 ) was 2.5- to 3-fold higher in fatal PE cases than in the New York City population as a whole. Carrier frequencies for prothrombin G20210A in fatal PE were 2- to 10-fold higher than reported frequencies in ethnically matched controls. Cumulative distribution curves showed that compared with whites, blacks and Hispanics died at significantly younger ages ( P P =0.001) and obesity ( P =0.002) are significantly associated with younger age at death. Conclusion— There are unique epidemiological differences in out-of-hospital fatal PE between ethnic groups in New York City. |
| Databáze: | OpenAIRE |
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