Undifferentiated Connective Tissue Disease and Interstitial Lung Disease: Trying to Define Patterns
| Autor: | María Laura Alberti, Martín Eduardo Fernández, Mayra Edith Mejía, Fabian Caro, Francisco Paulin, Jorge Rojas-Serrano, Heidegger Mateos Toledo |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Vital capacity Pathology medicine.medical_specialty High-resolution computed tomography Anti-nuclear antibody 03 medical and health sciences FEV1/FVC ratio 0302 clinical medicine Odds Ratio Humans Medicine 030212 general & internal medicine Undifferentiated Connective Tissue Diseases Aged Retrospective Studies medicine.diagnostic_test business.industry Interstitial lung disease Undifferentiated connective tissue disease General Medicine Middle Aged medicine.disease Connective tissue disease Logistic Models 030228 respiratory system Linear Models Female CTD Lung Diseases Interstitial business Follow-Up Studies |
| Zdroj: | Reumatología Clínica (English Edition). 14:75-80 |
| ISSN: | 2173-5743 |
| Popis: | To identify clinical or immunological features in patients with undifferentiated connective tissue disease (UCTD) associated interstitial lung disease (ILD), in order to group them and recognize different functional and high resolution computed tomography (HRCT) behavior.Retrospective cohort study. Patients meeting Kinder criteria for UCTD were included. We defined the following predictive variables: 'highly specific' connective tissue disease (CTD) manifestations (Raynaud's phenomenon, dry eyes or arthritis), high antinuclear antibody (ANA) titer (above 1: 320), and 'specific' ANA staining patterns (centromere, cytoplasmic and nucleolar patterns). We evaluated the following outcomes: change in the percentage of the predicted forced vital capacity (FVC%) during the follow-up period, and HRCT pattern.Sixty-six patients were included. Twenty-nine (43.94%) showed at least one 'highly specific' CTD manifestation, 16 (28.57%) had a 'specific' ANA staining pattern and 29 (43.94%) high ANA titer. Patients with 'highly specific' CTD manifestations were younger (mean [SD] 52 years [14.58] vs 62.08 years [9.46], P.001), were more likely men (10.34% vs 48.65%, P.001) and showed a smaller decline of the FVC% (median [interquartile range] 1% [-1 to 10] vs -6% [-16 to -4], P.006). In the multivariate analysis, the presence of highly specific manifestations was associated with improvement in the FVC% (B coefficient of 13.25 [95% confidence interval, 2.41 to 24.09]). No association was observed in relation to the HRCT pattern.The presence of 'highly specific' CTD manifestations was associated with female sex, younger age and better functional behavior. These findings highlight the impact of the clinical features in the outcome of patients with UCTD ILD. |
| Databáze: | OpenAIRE |
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