The evolution of mitral valve prolapse: insights from the Framingham Heart Study

Autor: Birgitta T. Lehman, Martin G. Larson, Ramachandran S. Vasan, Emelia J. Benjamin, Brianne Hackman, Ewa Osypiuk, Warren J. Manning, Jian Rong, Deborah L. Fuller, Plamen Stantchev, Robert A. Levine, Francesca N. Delling
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Pulmonary and Respiratory Medicine
Adult
Male
medicine.medical_specialty
Mitral prolapse
Computed tomography
030204 cardiovascular system & hematology
Article
030218 nuclear medicine & medical imaging
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Framingham Heart Study
Cardiac magnetic resonance imaging
Internal medicine
Physiology (medical)
Mitral valve
Epidemiology
medicine
Humans
Mitral valve prolapse
Longitudinal Studies
030212 general & internal medicine
cardiovascular diseases
Family history
Mitral regurgitation
Mitral Valve Prolapse
medicine.diagnostic_test
business.industry
valvular heart disease
Disease progression
Follow up studies
Middle Aged
medicine.disease
Surgery
Editorial
medicine.anatomical_structure
Massachusetts
Cardiology
Disease Progression
cardiovascular system
Commentary
Female
Cardiology and Cardiovascular Medicine
business
Follow-Up Studies
Cohort study
Popis: Background— Longitudinal studies of mitral valve prolapse (MVP) progression among unselected individuals in the community, including those with nondiagnostic MVP morphologies (NDMs), are lacking. Methods and Results— We measured longitudinal changes in annular diameter, leaflet displacement, thickness, anterior/posterior leaflet projections onto the annulus, coaptation height, and mitral regurgitation jet height in 261 Framingham Offspring participants at examination 5 who had available follow-up imaging 3 to 16 years later. Study participants included MVP (n=63); NDMs, minimal systolic displacement (n=50) and the abnormal anterior coaptation phenotype (n=10, with coaptation height >40% of the annulus similar to posterior MVP); plus 138 healthy referents without MVP or NDMs. At follow-up, individuals with MVP (52% women, 57±11 years) had greater increases of leaflet displacement, thickness, and jet height than referents (all P P Conclusions— NDM may evolve into MVP, highlighting the clinical significance of mild MVP expression. MVP progresses to significant mitral regurgitation over a period of 3 to 16 years in one-fourth of individuals in the community. Changes in mitral leaflet morphology are associated with both NDM and MVP progression.
Databáze: OpenAIRE
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