Expression of syndecan-1 in human placenta and decidua
| Autor: | Eeva Ekholm, O. Hirvonen, Harry Kujari, L. Anttila, P. Inki, V. Jokimaa |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Syndecans animal structures Blotting Western Syncytiotrophoblasts Biology Syndecan 1 Extracellular matrix Syncytiotrophoblast Pregnancy Placenta Decidua medicine Humans reproductive and urinary physiology Membrane Glycoproteins Antibodies Monoclonal Obstetrics and Gynecology Trophoblast Cell Differentiation Blotting Northern Immunohistochemistry Trophoblasts Cell biology carbohydrates (lipids) medicine.anatomical_structure Reproductive Medicine embryonic structures Immunology Chorionic villi Female Proteoglycans Syndecan-1 Chorionic Villi Developmental Biology |
| Zdroj: | Placenta. 19:157-163 |
| ISSN: | 0143-4004 |
| DOI: | 10.1016/s0143-4004(98)90004-2 |
| Popis: | Syndecan-1 is a cell surface heparan sulphate proteoglycan, which binds to the extracellular matrix (ECM), growth factors and antithrombin III. The early expression of syndecan-1 during mouse embryonic development suggests a potential role in the communication between the embryo and the ECM of decidua. Using immunohistochemical methods, the present study showed that the expression of syndecan-1 in the trophoblast cells changes along trophoblast differentiation. The syncytiotrophoblasts in the chorionic villi exhibited an apical expression of syndecan-1. This suggests that the expression is restricted to non-migrating, non-proliferating trophoblasts. The mode of syndecan-1 expression by human placental trophoblasts is independent of gestational age. The expression is not changed in miscarriages. In pre-eclampsia, the staining for syndecan-1 on the villous syncytiotrophoblast is weaker compared to normal pregnancy, but in placental bed the expression is similar. The unique apical localization of syndecan-1 in chorionic villi, not detected in any other tissues, suggests a potential role in fetomaternal communication probably via growth factor binding and in anticoagulation of intervillous circulation. |
| Databáze: | OpenAIRE |
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