Colonic spreading of a non-chlorofluorocarbon mesalazine rectal foam enema in patients with quiescent ulcerative colitis
| Autor: | G. Hooper, S. Marshall, J. S. McCRACKEN, Ian R. Wilding, C. J. Kenyon, J. Armbrecht, S. Chauhan, H. J. Staab |
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| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Time Factors Colon medicine.medical_treatment Enema Gastroenterology Descending colon chemistry.chemical_compound Mesalazine Pharmacokinetics Internal medicine Humans Medicine Pharmacology (medical) Intestinal Mucosa Mesalamine Radionuclide Imaging Chlorofluorocarbon Hepatology business.industry Anti-Inflammatory Agents Non-Steroidal Rectum Technetium medicine.disease Ulcerative colitis digestive system diseases Aminosalicylic Acids Kinetics medicine.anatomical_structure chemistry Rectal administration Rectal Foam Colitis Ulcerative business |
| Zdroj: | Alimentary Pharmacology & Therapeutics. 9:161-166 |
| ISSN: | 1365-2036 0269-2813 |
| DOI: | 10.1111/j.1365-2036.1995.tb00365.x |
| Popis: | SUMMARY Background: Rectal foam enemas provide for drug delivery to the distal colon for treatment of left sided ulcerative colitis. However, currently available formulations contain chlorofluorocarbons which are due to be phased out in the near future. The objective of this study was therefore to determine the degree of dispersion of a newly developed nonchlorofluorocarbon rectal foam preparation in ulcerative colitis patients. Methods: This was an open label non-controlled study of a single administration of a mesalazine foam enema (two actuations containing 2 g of mesalazine in approximately 120 mL foam) in 10 patients with quiescent ulcerative colitis. Spreading of the 99mTc-labelled foam enema was assessed over a 4-h period by the non-invasive technique of gamma scintigraphy. Results: All patients retained the enema for the full 4-h imaging period. In nine out of the 10 patients, the enema was observed to spread as far as the descending colon and on average 23% of the dose was present in the descending colon at 4 h post-dose. Conclusions: The extent of spreading observed in the study supports the use of the formulation in the treatment of left sided ulcerative colitis. |
| Databáze: | OpenAIRE |
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